mGluR Antibody

Code: CSB-PA309352XA01DLU

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Size:

0.1ml

0.1ml1ml

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Species Reactivity: Drosophila melanogaster (Fruit fly)

Raised in: Rabbit

Application: ELISA, WB (ensure identification of antigen)

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Target Background

Product Details

Uniprot NO.

P91685

Target Names

mGluR

Alternative Names

mGluR antibody; Glu-RA antibody; GluRA antibody; mGluRA antibody; CG11144Metabotropic glutamate receptor antibody; DmGluRA antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) mGluR protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Tested Applications

ELISA, WB (ensure identification of antigen)

Lead Time

Made-to-order (14-16 weeks)
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

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Target Background

Function(From Uniprot)

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors.

Gene References into Functions

transgenic flies expressing a number of GPCRs in the photoreceptor cells PMID:11964379
sterol-rich lipid rafts act as positive allosteric regulators of DmGluRA. PMID:12923296
Two roles were found for DmGluRA in presynaptic mechanisms: (1) modulation of presynaptic excitability properties important for control of activity-dependent neurotransmitter release and (2) modulation of synaptic architecture. PMID:15483129
Metabotropic glutamate receptor A (mGluRA) and fragile X mental retardation (Fmr) protein genetically interact in behavioral movement regulation. PMID:18280750
we report DmGluRA expression in most neuropile areas in both larvae and adults, but not in the lobes of the mushroom bodies PMID:18303583
DmGluRA mutations increase neuronal excitability by preventing PI3 kinase (PI3K) activation and consequently hyperactivating the transcription factor Foxo PMID:19043547

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Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Families

G-protein coupled receptor 3 family

Tissue Specificity

Expressed in the neurons of the larval CNS from the beginning of the first until the third instar. Expression in the third-instar larval CNS is restricted to a discrete number of somas and projections in the brain lobes and in the ventral ganglion. In the

Database Links

UNIGENE: Dm.1789

KEGG: dme:Dmel_CG11144

STRING: 7227.FBpp0305080

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