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Recombinant Drosophila melanogaster Histone deacetylase Rpd3 (Rpd3), partial

Recombinant Drosophila melanogaster Histone deacetylase Rpd3 (Rpd3), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Rpd3

Purity

>85% (SDS-PAGE)

Target Names

Rpd3

Uniprot NO.

Q94517

Alternative Names

HDAC1; Rpd3; CG7471; Histone deacetylase HDAC1; HD; EC 3.5.1.98

Species

Drosophila melanogaster (Fruit fly)

Source

Yeast

Expression Region

1-521

Target Protein Sequence

MQSHSKKRVC YYYDSDIGNY YYGQGHPMKP HRIRMTHNLL LNYGLYRKME IYRPHKATAD EMTKFHSDEY VRFLRSIRPD NMSEYNKQMQ RFNVGEDCPV FDGLYEFCQL SAGGSVAAAV KLNKQASEIC INWGGGLHHA KKSEASGFCY VNDIVLGILE LLKYHQRVLY IDIDVHHGDG VEEAFYTTDR VMTVSFHKYG EYFPGTGDLR DIGAGKGKYY AVNIPLRDGM DDDAYESIFV PIISKVMETF QPAAVVLQCG ADSLTGDRLG CFNLTVKGHG KCVEFVKKYN LPFLMVGGGG YTIRNVSRCW TYETSVALAV EIANELPYND YFEYFGPDFK LHISPSNMTN QNTSEYLEKI KNRLFENLRM LPHAPGVQIQ AIPEDAINDE SDDEDKVDKD DRLPQSDKDK RIVPENEYSD SEDEGEGGRR DNRSYKGQRK RPRLDKDTNS NKASSETSSE IKDEKEKGDG ADGEESTASN TNSNNNSNNK SDNDAGATAN AGSGSGSGSG AGAKGAKENN I
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation may constitute a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. For instance, deacetylation of histone H3 may be a prerequisite for the subsequent recruitment of the histone methyltransferase Su(var)3-9 to histones. Involved in position-effect variegation (PEV). In the larval brain, part of a regulatory network including the transcriptional repressors klu, dpn and E(spl)mgamma-HLH which is required for type II neuroblast self-renewal and for maintaining erm in an inactive state in intermediate neural progenitors (INP).

Gene References into Functions

Rpd3 accumulates in the nucleolus in the early stage of starvation, upregulates rRNA synthesis, maintains the polysome amount for translation, and finally increases stress tolerance proteins, such as autophagy-related proteins, to acquire starvation stress resistance. PMID:27907135
Hdac1/Rpd3 functions together with self-renewal transcriptional repressors to maintain the erm immature intermediate neural progenitors enhancer in an inactive but poised state in neuroblasts. PMID:28245922
This study tested the longevity effects of RPD3 on multiple nutrient levels. PMID:26647291
Rpd3 deacetylase in the heart plays a significant role in cardiac function and longevity to systemically modulate the fly's response to the environment PMID:26399365
the Atro-Rpd3 complex plays a conserved role to function as a Ci(R) corepressor. PMID:24385484
The dose of Rpd3 is critical for normal long-term memory. PMID:22195015
Work suggests that Drosophila telomere structure is epigenetically regulated by the histone deacetylase Rpd3. PMID:21625008
Our study suggests a specific function for the general chromatin remodeling factor Rpd3 in regulating dendrite targeting in neurons, largely through the postmitotic action of the Pros transcription factor. PMID:20660276
role of Rpd3 deacetylase and caloric restriction in longevity regulation PMID:12459580
findings indicate that Rpd3 contributes to Knirps repression activity in vivo PMID:16186109
DHDAC1 and -3 have distinct functions in the control of gene expression PMID:16632473