HDAC1 Antibody

Code: CSB-PA835986XA01DLU

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Size:

0.1ml

0.1ml1ml

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Species Reactivity: Drosophila melanogaster (Fruit fly)

Raised in: Rabbit

Application: ELISA, WB (ensure identification of antigen)

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Target Background

Product Details

Uniprot NO.

Q94517

Target Names

HDAC1

Alternative Names

HDAC1 antibody; Rpd3 antibody; CG7471 antibody; Histone deacetylase HDAC1 antibody; HD antibody; EC 3.5.1.98 antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) HDAC1 protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Tested Applications

ELISA, WB (ensure identification of antigen)

Lead Time

Made-to-order (14-16 weeks)
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

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Target Background

Function(From Uniprot)

Catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation may constitute a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. For instance, deacetylation of histone H3 may be a prerequisite for the subsequent recruitment of the histone methyltransferase Su(var)3-9 to histones. Involved in position-effect variegation (PEV). In the larval brain, part of a regulatory network including the transcriptional repressors klu, dpn and E(spl)mgamma-HLH which is required for type II neuroblast self-renewal and for maintaining erm in an inactive state in intermediate neural progenitors (INP).

Gene References into Functions

Rpd3 accumulates in the nucleolus in the early stage of starvation, upregulates rRNA synthesis, maintains the polysome amount for translation, and finally increases stress tolerance proteins, such as autophagy-related proteins, to acquire starvation stress resistance. PMID:27907135
Hdac1/Rpd3 functions together with self-renewal transcriptional repressors to maintain the erm immature intermediate neural progenitors enhancer in an inactive but poised state in neuroblasts. PMID:28245922
This study tested the longevity effects of RPD3 on multiple nutrient levels. PMID:26647291
Rpd3 deacetylase in the heart plays a significant role in cardiac function and longevity to systemically modulate the fly's response to the environment PMID:26399365
the Atro-Rpd3 complex plays a conserved role to function as a Ci(R) corepressor. PMID:24385484
The dose of Rpd3 is critical for normal long-term memory. PMID:22195015
Work suggests that Drosophila telomere structure is epigenetically regulated by the histone deacetylase Rpd3. PMID:21625008
Our study suggests a specific function for the general chromatin remodeling factor Rpd3 in regulating dendrite targeting in neurons, largely through the postmitotic action of the Pros transcription factor. PMID:20660276
role of Rpd3 deacetylase and caloric restriction in longevity regulation PMID:12459580
findings indicate that Rpd3 contributes to Knirps repression activity in vivo PMID:16186109
DHDAC1 and -3 have distinct functions in the control of gene expression PMID:16632473