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Recombinant Drosophila melanogaster Glutamate [NMDA] receptor subunit 1 (Nmdar1), partial

Recombinant Drosophila melanogaster Glutamate [NMDA] receptor subunit 1 (Nmdar1), partial

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MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Nmdar1

Purity

>85% (SDS-PAGE)

Target Names

Nmdar1

Uniprot NO.

Q24418

Alternative Names

Nmdar1; nmr; NR1; CG2902; Glutamate [NMDA] receptor subunit 1; DNMDAR-I; dNR1

Species

Drosophila melanogaster (Fruit fly)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors. Plays a role in associative learning and in long-term memory consolidation.

Gene References into Functions

Recent studies indicate that several risk genes for schizophrenia are within two degrees of separation from the N-methy-D-aspartate receptor (NMDAR), a subtype of glutamate receptor that is critical to synapse formation and synaptic plasticity.[review] PMID:26954593
NMDAR1 promotes sleep regulation in Drosophila. PMID:26023770
NMDA Receptor 1 plays a role in both behavioral responses to touch and in the formation of the actin-rich sensory filopodia. PMID:23103192
The study suggested that Mg(2+) block of NMDARs functions to suppress basal expression of a CREB repressor, thus permitting CREB-dependent gene expression upon LTM induction. PMID:22681692
NMDA receptor (dNR1) mediate associative olfactory learning and memory in Drosophila PMID:15823532
nmda receptor 1 regiure for long-term memory consolidation in Drosophila ellipsoid body. PMID:17982450
Distribution of the NR1 subunit of the NMDA receptor in the cerebral ganglia of the honeybee and fruit fly are similar; areas with the highest concentrations of NR1 subunits were identified and compared. PMID:18401728

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Subcellular Location

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, postsynaptic density.

Protein Families

Glutamate-gated ion channel (TC 1.A.10.1) family

Tissue Specificity

Highly expressed in adult heads: in the brain and ring gland. Low expression throughout the entire brain is also seen. Higher expression levels were observed in some scattered cell bodies and part of their fibers, including those from several pairs of DPM

Database Links

UNIGENE: Dm.3670

KEGG: dme:Dmel_CG2902

STRING: 7227.FBpp0078410

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