Nmdar1 Antibody

Code: CSB-PA634509XA01DLU

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Size:

20μl50μl100μl

US$83

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Species Reactivity: Drosophila melanogaster (Fruit fly)

Raised in: Rabbit

Application: ELISA, WB

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Target Background

Product Details

Uniprot NO.

Q24418

Target Names

Nmdar1

Alternative Names

Glutamate [NMDA] receptor subunit 1 (DNMDAR-I) (dNR1) Nmdar1 nmr NR1 CG2902

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) Nmdar1 protein (291-573)

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000

Protocols

ELISA Protocol Western Blotting(WB) Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Western Blot
Positive WB detected in: recombinant protein
All lanes: Nmdar1 Antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 34 kDa
Observed band size: 34 kDa

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors. Plays a role in associative learning and in long-term memory consolidation.

Gene References into Functions

Recent studies indicate that several risk genes for schizophrenia are within two degrees of separation from the N-methy-D-aspartate receptor (NMDAR), a subtype of glutamate receptor that is critical to synapse formation and synaptic plasticity.[review] PMID:26954593
NMDAR1 promotes sleep regulation in Drosophila. PMID:26023770
NMDA Receptor 1 plays a role in both behavioral responses to touch and in the formation of the actin-rich sensory filopodia. PMID:23103192
The study suggested that Mg(2+) block of NMDARs functions to suppress basal expression of a CREB repressor, thus permitting CREB-dependent gene expression upon LTM induction. PMID:22681692
NMDA receptor (dNR1) mediate associative olfactory learning and memory in Drosophila PMID:15823532
nmda receptor 1 regiure for long-term memory consolidation in Drosophila ellipsoid body. PMID:17982450
Distribution of the NR1 subunit of the NMDA receptor in the cerebral ganglia of the honeybee and fruit fly are similar; areas with the highest concentrations of NR1 subunits were identified and compared. PMID:18401728

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Subcellular Location

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, postsynaptic density.

Protein Families

Glutamate-gated ion channel (TC 1.A.10.1) family

Tissue Specificity

Highly expressed in adult heads: in the brain and ring gland. Low expression throughout the entire brain is also seen. Higher expression levels were observed in some scattered cell bodies and part of their fibers, including those from several pairs of DPM

Database Links

UNIGENE: Dm.3670

KEGG: dme:Dmel_CG2902

STRING: 7227.FBpp0078410

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