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Recombinant Drosophila melanogaster 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Hmgcr), partial

Recombinant Drosophila melanogaster 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Hmgcr), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Hmgcr

Uniprot NO.

P14773

Alternative Names

Hmgcr; HmG-CoAR; CG10367; 3-hydroxy-3-methylglutaryl-coenzyme A reductase; HMG-CoA reductase; EC 1.1.1.34

Species

Drosophila melanogaster (Fruit fly)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Synthesis of mevalonate for the production of non-sterol isoprenoids, which are essential for growth differentiation. Provides spatial information during embryogenesis to guide migrating primordial germ cells (the pole cells) from the ectoderm to the mesoderm. Also required for association of the pole cells with the gonadal mesoderm.

Gene References into Functions

The specificity and evolutionary conservation of the HMGCoAr pathway for germ cells suggest that an attractant common to invertebrates and vertebrates guides germ cells in early embryos. PMID:14960281

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Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Protein Families

HMG-CoA reductase family

Tissue Specificity

Highly expressed in embryonic gonadal mesoderm, where expression is initially broad, and then becomes restricted to a segmental pattern at stage 11. Expression is then further restricted to a cluster of cells in each of parasegments 10, 11 and 12, corresp

Database Links

UNIGENE: Dm.21259

KEGG: dme:Dmel_CG10367

STRING: 7227.FBpp0083842

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