Hmgcr Antibody

Code: CSB-PA010565XA01DLU

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Size:

0.1ml

0.1ml1ml

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Species Reactivity: Drosophila melanogaster (Fruit fly)

Raised in: Rabbit

Application: ELISA, WB (ensure identification of antigen)

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Target Background

Product Details

Uniprot NO.

P14773

Target Names

Hmgcr

Alternative Names

Hmgcr antibody; HmG-CoAR antibody; CG10367 antibody; 3-hydroxy-3-methylglutaryl-coenzyme A reductase antibody; HMG-CoA reductase antibody; EC 1.1.1.34 antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) Hmgcr protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Tested Applications

ELISA, WB (ensure identification of antigen)

Lead Time

Made-to-order (14-16 weeks)
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

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Target Background

Function(From Uniprot)

Synthesis of mevalonate for the production of non-sterol isoprenoids, which are essential for growth differentiation. Provides spatial information during embryogenesis to guide migrating primordial germ cells (the pole cells) from the ectoderm to the mesoderm. Also required for association of the pole cells with the gonadal mesoderm.

Gene References into Functions

The specificity and evolutionary conservation of the HMGCoAr pathway for germ cells suggest that an attractant common to invertebrates and vertebrates guides germ cells in early embryos. PMID:14960281

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Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Protein Families

HMG-CoA reductase family

Tissue Specificity

Highly expressed in embryonic gonadal mesoderm, where expression is initially broad, and then becomes restricted to a segmental pattern at stage 11. Expression is then further restricted to a cluster of cells in each of parasegments 10, 11 and 12, corresp

Database Links

UNIGENE: Dm.21259

KEGG: dme:Dmel_CG10367

STRING: 7227.FBpp0083842

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