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Recombinant Drosophila melanogaster Acetylcholinesterase (Ace), partial

Recombinant Drosophila melanogaster Acetylcholinesterase (Ace), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Ace

Uniprot NO.

P07140

Alternative Names

Ace; CG17907Acetylcholinesterase; AChE; EC 3.1.1.7) [Cleaved into: Acetylcholinesterase 16 kDa subunit; Acetylcholinesterase 55 kDa subunit]

Species

Drosophila melanogaster (Fruit fly)

Source

Yeast

Expression Region

39-619

Target Protein Sequence

VI DRLVVQTSSG PVRGRSVTVQ GREVHVYTGI PYAKPPVEDL RFRKPVPAEP WHGVLDATGL SATCVQERYE YFPGFSGEEI WNPNTNVSED CLYINVWAPA KARLRHGRGA NGGEHPNGKQ ADTDHLIHNG NPQNTTNGLP ILIWIYGGGF MTGSATLDIY NADIMAAVGN VIVASFQYRV GAFGFLHLAP EMPSEFAEEA PGNVGLWDQA LAIRWLKDNA HAFGGNPEWM TLFGESAGSS SVNAQLMSPV TRGLVKRGMM QSGTMNAPWS HMTSEKAVEI GKALINDCNC NASMLKTNPA HVMSCMRSVD AKTISVQQWN SYSGILSFPS APTIDGAFLP ADPMTLMKTA DLKDYDILMG NVRDEGTYFL LYDFIDYFDK DDATALPRDK YLEIMNNIFG KATQAEREAI IFQYTSWEGN PGYQNQQQIG RAVGDHFFTC PTNEYAQALA ERGASVHYYY FTHRTSTSLW GEWMGVLHGD EIEYFFGQPL NNSLQYRPVE RELGKRMLSA VIEFAKTGNP AQDGEEWPNF SKEDPVYYIF STDDKIEKLA RGPLAARCSF WNDYLPKVRS WAGTCDGDS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Rapidly hydrolyzes choline released into the synapse. It can hydrolyze butyrylthiocholine.

Gene References into Functions

1 engineered disulfide bridge, I327C/D375C increased stability to heat denaturation, urea, & organic solvents & provided protease resistance. The new disulfide bridge links the N-terminal domain (first 356 aa) to the C-terminal domain. PMID:16686937
Results provide insights into substrate and product traffic in the Drosophila melanogaster acetylcholinesterase active site gorge. PMID:18422651
kinetic studies show that it affects interactions with peripheral ligands and the entrance of some of the bulkier substrates PMID:18439026
molecular dynamics simulation reveals the insecticidal resistance mechanism of AChE and its mutation PMID:19263097