Recombinant Dog Erythropoietin (EPO)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

EPO

Uniprot NO.

P33707

Species

Canis lupus familiaris (Dog) (Canis familiaris)

Source

Yeast

Expression Region

41-206

Target Protein Sequence

APPRLICDSR VLERYILEAR EAENVTMGCA QGCSFSENIT VPDTKVNFYT WKRMDVGQQA LEVWQGLALL SEAILRGQAL LANASQPSET PQLHVDKAVS SLRSLTSLLR ALGAQKEAMS LPEEASPAPL RTFTVDTLCK LFRIYSNFLR GKLTLYTGEA CRRGDR
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.

Gene References into Functions

Developmental and compensatory lung growth involve paracrine erythropoietin signaling with parallel upregulation but differential processing of the erythropoietin receptor. PMID:15286000
apical secretion of EPO involves a cholesterol-dependent mechanism probably not involving lipid rafts PMID:15916748

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Subcellular Location

Secreted.

Protein Families

EPO/TPO family

Tissue Specificity

Produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals.

Database Links

UNIGENE: Cfa.3871

KEGG: cfa:404002

STRING: 9615.ENSCAFP00000038507

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