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Recombinant Dog C-X-C chemokine receptor type 4 (CXCR4), partial

Recombinant Dog C-X-C chemokine receptor type 4 (CXCR4), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

CXCR4

Purity

>85% (SDS-PAGE)

Target Names

CXCR4

Uniprot NO.

Q3LSL6

Species

Canis lupus familiaris (Dog) (Canis familiaris)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade. Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival.

Gene References into Functions

interaction with CXCL12 to promote cell migration and invasion of hemangiosarcoma PMID:26337509
Clusterin expression may increase cardiac progenitor cell migration via increasing CXCR4 expression and SDF-1/chemokine receptor signaling in a PI3/Akt-dependent manner. PMID:20813109
CXCR4 is excluded as the cause of trapped neutrophil syndrome in Border Collies. PMID:16441310
The amino acid sequence encoding CXCR4 showed the structural characteristics of seven transmembrane domain G protein-coupled receptors. PMID:17316828
The expression of CXCR4 in canine immortalized cell lines and naturally occurring tumor samples and the role of CXCR4 in cell migration in cell lines are reported. PMID:18466248