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Recombinant Danio rerio Transcription factor Sox-2 (sox2)

Recombinant Danio rerio Transcription factor Sox-2 (sox2)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

sox2

Purity

>85% (SDS-PAGE)

Target Names

sox2

Uniprot NO.

Q6P0E1

Alternative Names

sox2; zgc:65860; zgc:77389; Transcription factor Sox-2

Species

Danio rerio (Zebrafish) (Brachydanio rerio)

Source

Yeast

Expression Region

1-315

Target Protein Sequence

MYNMMETELK PPAPQPNTGG TGNTNSSGNN QKNSPDRIKR PMNAFMVWSR GQRRKMAQEN PKMHNSEISK RLGAEWKLLS ESEKRPFIDE AKRLRALHMK EHPDYKYRPR RKTKTLMKKD KYTLPGGLLA PGGNGMGAGV GVGAGLGAGV NQRMDSYAHM NGWTNGGYGM MQEQLGYPQH PSLNAHNTAQ MQPMHRYDMS ALQYNSMTNS QTYMNGSPTY SMSYSQQSTP GMTLGSMGSV VKSESSSSPP VVTSSSHSRA GQCQTGDLRD MISMYLPGAE VQDQSAQSRL HMSQHYQSAP VPGTTINGTI PLSHM
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Transcriptional activator. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal.

Gene References into Functions

Findings indicate a pivotal role for ZNF32 function in SOX2 expression and regeneration regulation. PMID:27626680
Both sox2 and p27kip are regulated by the retinoic acid signal pathway and are essential for hair cell regeneration. PMID:26609166
a role of Sox2 as one of the proliferation initiators in ependymal cells after spinal cord injury PMID:25150399
Sox2 is identified as the unknown factor responsible for pineal photoreceptor prepatterning and performs this function independently of the BMP signaling. PMID:24498133
By western blot three protein bands of 28 kDa, 34 kDa (main band), and 38 kDa were detected in the brain of animals 180 days post-fertilizaton. PMID:20734413
significant decreases in sox2 (up to 4-fold) expression following chilling and increase of sox2 (up to 3-fold) during warming of chilled embryos. PMID:21820425
sox2 is required for hair cell survival, as well as for transdifferentiation of support cells into hair cells during regeneration PMID:20025865
shows the occurrence and cell localization of the Sox-2 in chemosensory and mechanosensory organs of zebrafish during the embryonic stage to adult, suggest an involvement of Sox-2 in cell renewal of zebrafish sensory organs PMID:19800392
zebrafish sox2 gene is strongly expressed in neuromast progenitor cells, including those of the migrating lateral line PMID:17443814
Sox2 overlapping transcript has multiple transcription start sites associated with genomic features that indicate regulated expression, including highly conserved elements and chromatin marks characteristic of gene promoters. PMID:19767420

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Subcellular Location

Nucleus. Cytoplasm.

Tissue Specificity

At the shield stage, expressed uniformly in the future ectoderm. At the 75-80% epiboly stage, becomes localized to the presumptive neuroectoderm; strong expression in the presumptive forebrain, weak expression in the presumptive spinal cord. At the tail b

Database Links

UNIGENE: Dr.5379

KEGG: dre:378723

STRING: 7955.ENSDARP00000095266

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