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Recombinant Danio rerio Sphingosine 1-phosphate receptor 1 (s1pr1), partial

Recombinant Danio rerio Sphingosine 1-phosphate receptor 1 (s1pr1), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Target Background

Product Details

Abbreviation

s1pr1

Purity

>85% (SDS-PAGE)

Target Names

s1pr1

Uniprot NO.

Q9DDK4

Alternative Names

s1pr1; edg1; Sphingosine 1-phosphate receptor 1; S1P receptor 1; S1P1; Sphingosine 1-phosphate receptor Edg-1; S1P receptor Edg-1

Species

Danio rerio (Zebrafish) (Brachydanio rerio)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate.

Gene References into Functions

Wnt/beta-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling in the process of neovascularization of the central nervous system and blood-brain barrier formation. PMID:30451830
Individual s1prs showed unique expression patterns with some overlapping expression domains during early embryogenesis. PMID:26094551
Sphingosine 1-phosphate receptor signaling regulates proper embryonic vascular patterning PMID:23229546
Report role for S1PR1 in regulation venous endothelial barrier function. PMID:22837470