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Recombinant Danio rerio Fibroblast growth factor 3 (fgf3)

Recombinant Danio rerio Fibroblast growth factor 3 (fgf3)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

fgf3

Uniprot NO.

P48802

Species

Danio rerio (Zebrafish) (Brachydanio rerio)

Source

Yeast

Expression Region

19-256

Target Protein Sequence

ES LAPRLTRTPR APCARGQACD PRQRRDAGGR GGVYEHLGGA PRRRKLYCAT KYHLQIHPNG KIDGSLEENN PLSILEITAV DVGVVAIKGL FSGRYLAMNE KGRLYASEVF NRECEFLERI HELGYNTYAS RHHATTQPPP TGSGIGGSKR RASSKRQWYV SINGKGRPRR GFKTRSTDKA SLFLPRVLAN KDHEMVRKLR ESQRHHTGSH RAPVGRAERR RRRHRGSKGH NRRADI
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation.

Gene References into Functions

Pharmacological inhibition of FGF signaling or a mutation in the fgf3 gene can compensate the gain of caudal hypothalamic dopaminergic neurons in cnot8m1061 mutants, indicating a role for Fgf3 in control of development of this dopaminergic population PMID:25478689
Fgf10b participates in a late phase of otic induction and, in combination with fgf3, is especially critical for epibranchial induction. PMID:24677486
Fgf3 and Fgf10a work in concert to promote maturation of the epibranchial placodes in zebrafish. PMID:24358375
Myogenic factor (Myf)5 modulates craniofacial cartilage development through the fgf3 signaling pathway. PMID:23992145
Data indicate that foxi1 is expressed in branchial arch ectoderm and endoderm, and morpholino knock-down of foxi1 causes apoptosis of neural crest in the branchial arches, which is rescued by fgf3. PMID:24650709
Fgf10 and Fgf3 secreted from the forming neurohypophysis exert direct guidance effects on hypothalamic neurosecretory axons. PMID:23404108
In lia(-/-) (fgf3(-/-)) mutants, anterior otic character is reduced, but not lost altogether. PMID:21831919
Requirement for endoderm and FGF3 in ventral head skeleton formation PMID:12223404
Results show that fibroblast growth factor 3 signaling from the ventral diencephalon is required to induce the expression of lim3, pit1 and other pituitary-specific genes in the underlying adenohypophyseal progenitor cells. PMID:15229178
Results suggest that Fgf3 is a major endodermal determinant required for epibranchial placode neurogenesis. PMID:16077091
fgf3 can act as otic inducers PMID:17239227
The FGF3 signal delineates the melanotrope and corticotrope lineage boundary, contributing to establishment of the pituitary pars distalis and pars intermedia. PMID:18514643
rosettes form cyclically from a progenitor pool at the leading zone of the posterior lateral line primordium as neuromasts are deposited from trailing region; fgf3/10 signals localized to leading zone required for rosette formation & primordium migration PMID:18583612
morphogenetic tissue rearrangements during eye evagination result in progenitor cells in the nasal half of the retina primordium being brought into proximity to the sources of three fibroblast growth factors, Fgf8/3/24, outside the eye. PMID:19823566