Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation.
Gene References into Functions
Pharmacological inhibition of FGF signaling or a mutation in the fgf3 gene can compensate the gain of caudal hypothalamic dopaminergic neurons in cnot8m1061 mutants, indicating a role for Fgf3 in control of development of this dopaminergic populationPMID:25478689
Fgf10b participates in a late phase of otic induction and, in combination with fgf3, is especially critical for epibranchial induction.PMID:24677486
Fgf3 and Fgf10a work in concert to promote maturation of the epibranchial placodes in zebrafish.PMID:24358375
Myogenic factor (Myf)5 modulates craniofacial cartilage development through the fgf3 signaling pathway.PMID:23992145
Data indicate that foxi1 is expressed in branchial arch ectoderm and endoderm, and morpholino knock-down of foxi1 causes apoptosis of neural crest in the branchial arches, which is rescued by fgf3.PMID:24650709
Fgf10 and Fgf3 secreted from the forming neurohypophysis exert direct guidance effects on hypothalamic neurosecretory axons.PMID:23404108
In lia(-/-) (fgf3(-/-)) mutants, anterior otic character is reduced, but not lost altogether.PMID:21831919
Requirement for endoderm and FGF3 in ventral head skeleton formationPMID:12223404
Results show that fibroblast growth factor 3 signaling from the ventral diencephalon is required to induce the expression of lim3, pit1 and other pituitary-specific genes in the underlying adenohypophyseal progenitor cells.PMID:15229178
Results suggest that Fgf3 is a major endodermal determinant required for epibranchial placode neurogenesis.PMID:16077091
The FGF3 signal delineates the melanotrope and corticotrope lineage boundary, contributing to establishment of the pituitary pars distalis and pars intermedia.PMID:18514643
rosettes form cyclically from a progenitor pool at the leading zone of the posterior lateral line primordium as neuromasts are deposited from trailing region; fgf3/10 signals localized to leading zone required for rosette formation & primordium migrationPMID:18583612
morphogenetic tissue rearrangements during eye evagination result in progenitor cells in the nasal half of the retina primordium being brought into proximity to the sources of three fibroblast growth factors, Fgf8/3/24, outside the eye.PMID:19823566