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Recombinant Arabidopsis thaliana Histone H3.3 (HTR4)

Recombinant Arabidopsis thaliana Histone H3.3 (HTR4)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

HTR4

Uniprot NO.

P59169

Alternative Names

HTR4; At4g40030; T5J17.200;; HTR5; At4g40040; T5J17.210;; HTR8; At5g10980; T30N20_250; T5K6.6Histone H3.3; Histone H3.2

Species

Arabidopsis thaliana (Mouse-ear cress)

Source

Yeast

Expression Region

2-136

Target Protein Sequence

ARTKQTARK STGGKAPRKQ LATKAARKSA PTTGGVKKPH RYRPGTVALR EIRKYQKSTE LLIRKLPFQR LVREIAQDFK TDLRFQSHAV LALQEAAEAY LVGLFEDTNL CAIHAKRVTI MPKDIQLARR IRGERA
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Gene References into Functions

Gene body methylation is likely shaped by H3.3 dynamics in conjunction with transcriptional activity. PMID:28521766
Clustered pathways are characterized by distinct chromatin signatures of H3K27me3 and H2A.Z, associated with cluster repression and activation, respectively, and represent discrete windows of co-regulation in the genome. PMID:26895889

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Subcellular Location

Nucleus. Chromosome. Nucleus, nucleolus.

Protein Families

Histone H3 family

Tissue Specificity

Ubiquitous.

Database Links

UNIGENE: At.10968

KEGG: ath:AT4G40030

STRING: 3702.AT5G10980.1

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