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Recombinant Arabidopsis thaliana DNA repair protein RAD50 (RAD50), partial

Recombinant Arabidopsis thaliana DNA repair protein RAD50 (RAD50), partial

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Source
Conjugate
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Target Background

Product Details

Abbreviation

RAD50

Purity

>85% (SDS-PAGE)

Target Names

RAD50

Uniprot NO.

Q9SL02

Alternative Names

RAD50; At2g31970; F22D22.28; DNA repair protein RAD50; AtRAD50; EC 3.6.-.-

Species

Arabidopsis thaliana (Mouse-ear cress)

Source

Yeast

Expression Region

1-1316

Target Protein Sequence

MSTVDKMLIK GIRSFDPENK NVVTFFRPLT LIVGANGAGK TTIIECLKVS CTGELPPNAR SGHSFIHDPK VAGETETKAQ IKLRFKTAAG KDVVCIRSFQ LTQKASKMEY KAIESVLQTI NPHTGEKVCL SYRCADMDRE IPALMGVSKA ILENVIFVHQ DESNWPLQDP STLKKKFDDI FSATRYTKAL EVIKKLHKDQ AQEIKTFKLK LENLQTLKDA AYKLRESIAQ DQERTESSKV QMLELETSVQ KVDAEVHNKE MMLKDLRKLQ DQVSIKTAER STLFKEQQRQ YAALPEENED TIEELKEWKS KFEERLALLG TKIRKMEREM VDTETTISSL HNAKTNYMLE ISKLQTEAEA HMLLKNERDS TIQNIFFHYN LGNVPSTPFS TEVVLNLTNR IKSRLGELEM DLLDKKKSNE TALSTAWDCY MDANDRWKSI EAQKRAKDEI KMGISKRIEE KEIERDSFEF EISTVDVKQT DEREKQVQVE LERKTKQNSE RGFESKIEQK QHEIYSLEHK IKTLNRERDV MAGDAEDRVK LSLKKTEQEN LKKKHKKIID ECKDRIRGVL KGRLPPEKDM KREIVQALRS IEREYDDLSL KSREAEKEVN MLQMKIQEVN NSLFKHNKDT ESRKRYIESK LQALKQESVT IDAYPKLLES AKDKRDDRKR EYNMANGMRQ MFEPFEKRAR QEHSCPCCER SFTADEEASF IKKQRVKASS TGEHLKALAV ESSNADSVFQ QLDKLRAVFE EYSKLTTEII PLAEKTLQEH TEELGQKSEA LDDVLGISAQ IKADKDSIEA LVQPLENADR IFQEIVSYQK QIEDLEYKLD FRGLGVKTME EIQSELSSLQ SSKDKLHGEL EKLRDDQIYM ERDISCLQAR WHAVREEKAK AANLLRDVTK AEEDLERLAE EKSQLDLDVK YLTEALGPLS KEKEQLLSDY NDMKIRRNQE YEELAEKKRN YQQEVEALLK ASYKINEYHD LKKGERLDDI QEKQRLSDSQ LQSCEARKNE LAGELNRNKD LMRNQDQLRR NIEDNLNYRT TKAKVEELTR EIESLEEQIL NIGGIAAVEA EIVKILRERE RLLSELNRCR GTVSVYESSI SKNRVELKQA QYKDIDKRHF DQLIQLKTTE MANKDLDRYY NALDKALMRF HTMKMEEINK IIRELWQQTY RGQDMDYIRI HSDSEGAGTR SYSYKVLMQT GDTELEMRGR CSAGQKVLAS LIIRLALAET FCLNCGILAL DEPTTNLDGP NSESLAGALL RIMEDRKGQE NFQLIVITHD ERFAQMIGQR QHAEKYYRVA KDDMQHSIIE AQEIFD
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Implicated in double-strand breaks (DSBs) repair by non-homologous end joining (NHEJ). Involved in telomere maintenance. Involved in telomerase action on chromosome ends. Required during meiosis for both male and female gametophytic development, for pairing and synapsis of homologous chromosomes during the early stages of meiotic recombination, especially during the pachytene stage of the first division.

Gene References into Functions

Data show that the product of the PHS1 gene is a cytoplasmic protein that functions by controlling transport of RAD50 from cytoplasm to the nucleus. PMID:19918061
The protective role of Rad50 protein on shortened telomeres results from its action in constraining recombination to sister chromatids and thus avoiding end-to-end interactions. PMID:16990794

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Subcellular Location

Nucleus. Chromosome, telomere.

Protein Families

SMC family, RAD50 subfamily

Tissue Specificity

Widely expressed, predominantly in meristematic and reproductive tissues.

Database Links

UNIGENE: At.65745

KEGG: ath:AT2G31970

STRING: 3702.AT2G31970.1

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