RAD50 Antibody

Code: CSB-PA874457XA01DOA

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Size:

0.1ml

0.1ml1ml

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Species Reactivity: Arabidopsis thaliana

Raised in: Rabbit

Application: ELISA, WB (ensure identification of antigen)

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Target Background

Product Details

Uniprot NO.

Q9SL02

Target Names

RAD50

Alternative Names

RAD50 antibody; At2g31970 antibody; F22D22.28 antibody; DNA repair protein RAD50 antibody; AtRAD50 antibody; EC 3.6.-.- antibody

Raised in

Rabbit

Species Reactivity

Arabidopsis thaliana

Immunogen

Recombinant Arabidopsis thaliana RAD50 protein

Immunogen Species

Arabidopsis thaliana (Mouse-ear cress)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Tested Applications

ELISA, WB (ensure identification of antigen)

Lead Time

Made-to-order (14-16 weeks)
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

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Target Background

Function(From Uniprot)

Implicated in double-strand breaks (DSBs) repair by non-homologous end joining (NHEJ). Involved in telomere maintenance. Involved in telomerase action on chromosome ends. Required during meiosis for both male and female gametophytic development, for pairing and synapsis of homologous chromosomes during the early stages of meiotic recombination, especially during the pachytene stage of the first division.

Gene References into Functions

Data show that the product of the PHS1 gene is a cytoplasmic protein that functions by controlling transport of RAD50 from cytoplasm to the nucleus. PMID:19918061
The protective role of Rad50 protein on shortened telomeres results from its action in constraining recombination to sister chromatids and thus avoiding end-to-end interactions. PMID:16990794

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Subcellular Location

Nucleus. Chromosome, telomere.

Protein Families

SMC family, RAD50 subfamily

Tissue Specificity

Widely expressed, predominantly in meristematic and reproductive tissues.

Database Links

UNIGENE: At.65745

KEGG: ath:AT2G31970

STRING: 3702.AT2G31970.1

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