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Recombinant Arabidopsis thaliana ABC transporter C family member 1 (ABCC1), partial

Recombinant Arabidopsis thaliana ABC transporter C family member 1 (ABCC1), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Target Background

Product Details

Abbreviation

ABCC1

Purity

>85% (SDS-PAGE)

Target Names

ABCC1

Uniprot NO.

Q9C8G9

Alternative Names

ABCC1; EST1; MRP1; At1g30400; T4K22.12ABC transporter C family member 1; ABC transporter ABCC.1; AtABCC1; EC 7.6.2.2; ATP-energized glutathione S-conjugate pump 1; Glutathione S-conjugate-transporting ATPase 1; Multidrug resistance-associated protein 1

Species

Arabidopsis thaliana (Mouse-ear cress)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Pump for glutathione S-conjugates. Mediates the transport of S-(2,4-dinitrophenyl)-glutathione (DNP-GS), GSSG, cyanidin 3-glucoside-GS (C3G-GS) and metolachlor-GS (MOC-GS).

Gene References into Functions

Data indicate that phosphorylation of serine Ser846 is required for the arsenic (As) resistance function of ATP-Binding Cassette (ABC) transporter ABCC1 (AtABCC1). PMID:28130831
MRP1 is important for vacuolar accumulation of antifolates as well as tolerance against arsenic, both of which involved phosphorylation in the serine triads at the C terminal nucleotide binding domain of MRP1. PMID:27428365
atmrp1 knock-out mutants are more sensitive than wild-type plants to growth retardation by nanomolar concentrations of MTX, and this is associated with impaired vacuolar antifolate sequestration. PMID:19136566

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Subcellular Location

Vacuole membrane; Multi-pass membrane protein. Note=Tonoplast.

Protein Families

ABC transporter superfamily, ABCC family, Conjugate transporter (TC 3.A.1.208) subfamily

Tissue Specificity

Ubiquitous, with higher levels in leaves and stems and lower levels in roots. Localized in the root apex, root hair tips and root epidermis.

Database Links

UNIGENE: At.21491

KEGG: ath:AT1G30400

STRING: 3702.AT1G30400.1

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