TOMM20 Antibody

CSB-PA618983ESR2HU

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20μl50μl100μl

US$83

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Species Reactivity: Human, Mouse

Raised in: Rabbit

Application: ELISA, WB, IHC, IF

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Product Details
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Target Background

Product Details

Uniprot NO.

Q15388

Target Names

TOMM20

Alternative Names

KIAA0016 antibody; MAS20 antibody; MGC117367 antibody; Mitochondrial 20 kDa outer membrane protein antibody; Mitochondrial import receptor subunit TOM20 homolog antibody; MOM19 antibody; Outer mitochondrial membrane receptor Tom20 antibody; TOM20 antibody; TOM20_HUMAN antibody; TOMM20 antibody; Translocase of outer mitochondrial membrane 20 homolog (yeast) antibody; Translocase of outer mitochondrial membrane 20 homolog type II antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Mitochondrial import receptor subunit TOM20 homolog protein (20-145AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200
IF	1:50-1:200

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Protocols

ELISA Protocol Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol Immunofluorescence (IF) Protocol

Datasheet & COA

Antibody FAQs

Images

Western blot
All lanes: Mitochondrial import receptor subunit TOM20 homolog antibody at 3μg/ml
Lane 1: Mouse brain tissue
Lane 2: Hela whole cell lysate
Lane 3: Mouse liver tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 16 kDa
Observed band size: 16 kDa
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA618983ESR2HU at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using CSB-PA618983ESR2HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Description

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Citations

An Image-Based High-Throughput and High-Content Drug Screening Method Based on Microarray and Expansion Microscopy J Xie,/,2023

Target Background

Function

Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore. Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases.

Gene References into Functions

TOMM20 and MCT1 were highly expressed in diffuse large B-cell lymphoma lymphocytes, indicating an OXPHOS phenotype, whereas non-neoplastic lymphocytes in the control samples did not express these markers. PMID:29248132
TOMM20, MCT1, and MCT4 expression was significantly different in Hodgkin and Reed Sternberg (HRS) cells. HRS have high expression of TOMM20, while tumor associated macrophages have absent TOMM20 expression. Tumor-infiltrating lymphocytes have low TOMM20 expression. Reactive lymph nodes in contrast to cHL tumors had low TOMM20, MCT1, and MCT4 expression in lymphocytes and macrophages. PMID:29248133
Gsk3beta and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease PMID:27503909
TOMM20 protein is highly expressed in both anaplastic thyroid cancer and papillary thyroid cancer compared to non-cancerous thyroid tissue. PMID:26615136
Tom20 was ubiquitously distributed in the organ of Corti, allowing well-delineated visualization of inner and outer hair cells. In the inner ear of aged subjects with Meniere's disease, there was decreased expression of Tom20. PMID:23165776
a novel model in which Tom20 binds Tom70 to facilitate preprotein release from the chaperones by competition PMID:21771790
Tom34 unlike Tom20 does not interact with the leader sequences of mitochondrial precursor proteins PMID:11913975
the cytosolic domains of Tom20 and Tom22 function to maintain their substrate preproteins unfolded and prevent them from aggregating on the mitochondrial surface PMID:14699115