TNFRSF10C Antibody

Code: CSB-PA08189A0Rb

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US$83

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Species Reactivity: Human

Raised in: Rabbit

Application: ELISA, IF

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Target Background

Product Details

Uniprot NO.

O14798

Target Names

TNFRSF10C

Alternative Names

TNFRSF10C antibody; DCR1 antibody; LIT antibody; TRAILR3 antibody; TRID antibody; UNQ321/PRO366 antibody; Tumor necrosis factor receptor superfamily member 10C antibody; Antagonist decoy receptor for TRAIL/Apo-2L antibody; Decoy TRAIL receptor without death domain antibody; Decoy receptor 1 antibody; DcR1 antibody; Lymphocyte inhibitor of TRAIL antibody; TNF-related apoptosis-inducing ligand receptor 3 antibody; TRAIL receptor 3 antibody; TRAIL-R3 antibody; TRAIL receptor without an intracellular domain antibody; CD antigen CD263 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Tumor necrosis factor receptor superfamily member 10C protein (26-236AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Tested Applications

ELISA, IF

Recommended Dilution

Application	Recommended Dilution
IF	1:50-1:200

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Immunofluorescent analysis of A549 cells using CSB-PA08189A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Immunofluorescent analysis of HepG2 cells using CSB-PA08189A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Target Background

Function(From Uniprot)

Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.

Gene References into Functions

High levels of TRAIL-R3 and CCR-2 expression in tumor epithelial cells identified patients with early breast cancer with poor outcomes. PMID:28420351
DcR1 levels in serum sample which were significantly lower in AMD patients. PMID:24534820
DcR1 upregulation mediates temozolomide resistance. PMID:25808868
GATA4 and DcR1 promoter hypermethylation is tumor specific event in glioblastoma but they promoter methylation cannot be considered as a prognostic marker of glioblastoma survival. PMID:23320456
Primary EOC is associated to a lower TRAIL-R3 expression. PMID:22555108
Data show that about 20% of AML patients highly expressed decoy receptor TRAIL-R3, which was strongly correlated to a shortened overall survival. PMID:21281967
Decoy receptors DcR1 and DcR2 on CD8+ T cells, but not on CD4-positive T cells, are positively correlated with patients' DAS scores. PMID:20799941
Results suggest that DcR1 expression occurs in a subset of endometrial carcinomas and may contribute to resistance to TRAIL-induced apoptosis. PMID:19936781
analysis of the transcription initiation sites and promoter structure of the TRAIL-R3 gene PMID:12417331
cloned and characterized a p53 consensus element located within the first intron of the TRAIL-R3 gene PMID:14623878
Our results demonstrate that DcR1 and DcR2 genes are frequently methylated in various tumor types, and aberrant methylation was the cause for silencing of DcR1 and DcR2 expression. PMID:14999791
The DcR1 had no death domain and was anchored to the membrane via a glycophosphatidyl inositol tail. PMID:15538968
Resistance to TRAIL-induced apoptosis in acute myeloid leukemia cells is associated with expression of TRAIL-R3. PMID:15921376
tryptophol induces apoptosis through DR5 and the resistance of PBL to tryptophol-induced apoptosis might be due to competition from DcR1 PMID:17690453
p53 negatively regulates oxaliplatin-mediated TRAIL-induced apoptotic activity through DcR1 upregulation. PMID:18345033
TRAILR3 (TNF-related apoptosis inducing ligand receptor 3) levels were significantly higher in lung parenchyma in subjects with emphysema PMID:18511705
Liver metastases with low DcR1/TNFRSF10C mRNA expression were more likely to present with extrahepatic metastases PMID:18590575
inactivation of TNFRSF10C by chromosomal deletion and promoter methylation may play an important role in prostate cancer development PMID:19035483
Low DCR1 is associated with non-small cell lung cancer. PMID:19661294

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Subcellular Location

Cell membrane; Lipid-anchor, GPI-anchor.

Tissue Specificity

Higher expression in normal tissues than in tumor cell lines. Highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung and heart.

Database Links

HGNC: 11906

UNIGENE: Hs.655801

KEGG: hsa:8794

STRING: 9606.ENSP00000349324

OMIM: 603613

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