TAS2R1 Antibody

Code: CSB-PA020241

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Size:

50μg100μg

US$119

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Species Reactivity: Human

Raised in: Rabbit

Application: WB, IF, ELISA

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Target Background

Product Details

Uniprot NO.

Q9NYW7

Target Names

TAS2R1

Alternative Names

TAS2R1; Taste receptor type 2 member 1; T2R1; Taste receptor family B member 7; TRB7

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthesized peptide derived from the N-terminal region of Human T2R1.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Tested Applications

WB, IF, ELISA

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Target Background

Function(From Uniprot)

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.

Gene References into Functions

TAS2R agonists block signaling downstream of phosphatidylinositol 3-kinase PMID:26684251
Expression and functional activity of the bitter taste receptors TAS2R1 and TAS2R38 in human keratinocytes PMID:25573083
Intracellular signaling and cell mechanics using isolated human airway smooth muscle, mouse tracheal responses, and human bronchial responses to characterize TAS2R relaxation in the context of beta(2)AR desensitization. PMID:22683571
The formation of a short helical segment in intracellular loop II may be necessary for the activation of hTAS2R1. PMID:21619450
Structural basis of activation of bitter taste receptor T2R1 and comparison with Class A G-protein-coupled receptors (GPCRs). PMID:21852241
The ligand binding pocket in T2R1 is present on the extracellular surface of the receptor, and is formed by the transmembrane helices 1, 2, 3 and 7 and with extracellular loops 1 and 2 forming a cap like structure on the binding pocket. PMID:20599705