TAS1R3 Antibody

Code: CSB-PA752534ESR2HU

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20μl50μl100μl

US$83

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Species Reactivity: Human

Raised in: Rabbit

Application: ELISA, WB, IHC

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Product Details
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Target Background

Product Details

Uniprot NO.

Q7RTX0

Target Names

TAS1R3

Alternative Names

G protein coupled receptor antibody; Sac antibody; Saccharin preference antibody; Sweet taste receptor T1R3 antibody; T1 R3 antibody; T1R 3 antibody; T1R3 antibody; TAS1 R3 antibody; TAS1R 3 antibody; TAS1R3 antibody; Taste receptor type 1 member 3 antibody; Taste receptor type 1 member 3 precursor antibody; TR 3 antibody; TR3 antibody; TS1R3_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Taste receptor type 1 member 3 protein (400-570AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Western Blot
Positive WB detected in: PC-3 whole cell lysate(20µg), MCF7 whole cell lysate(20µg), JK whole cell lysate(20µg)
All lanes: TAS1R3 antibody at 1:500
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 94 kDa
Observed band size: 100 kDa
Exposure time: 300s
Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA752534ESR2HU at dilution of 1:100

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Target Background

Function(From Uniprot)

Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose. Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses.

Gene References into Functions

Regarding "consumption of carbohydrates (% energy) and higher amount of sweet foods, respectively...no associations were found for the TAS1R3 alleles." PMID:29110749
TAS1R3 gene rs307355 polymorphism found independent risk factor for dental caries experience by logistic regression & increased risk of caries. Moderate caries (4-7 caries) found to be associated w/TAS1R3 rs307355 heterozygous genotype PMID:25924601
T1R3 gene expression in the tongue is suppressed by chemotherapy. PMID:26422579
The transcripts of TAS1R3 and UCN2 in peripheral blood cells may be considered potential biomarkers of consumption of sugary and fatty food, respectively, to complement data of food-intake questionnaires. PMID:26168276
Five amino acid residues in cysteine-rich domain of human T1R3 were involved in the response for sweet-tasting protein, thaumatin PMID:23370115
T1R3 is a receptor responsible for the detection of calcium by taste. PMID:22773945
Overexpressed the human N-terminal domain of T1R3 in E. coli and found that the refolded protein behaves as a dimer; showed that hT1R3-NTD is functional and capable of binding sucralose with an affinity in the millimolar range. PMID:22450161
amino acid substitutions (F749S and R757C), located in the transmembrane domain of T1R3, severely impair receptor functions in vitro PMID:21422378
The sweet taste receptors (alpha-gustducin and T1R3) are involved in glucose-stimulated secretion of GLP-1 and PYY. PMID:21324568
Allelic polymorphism within the TAS1R3 promoter is associated with human taste sensitivity to sucrose. PMID:19559618
The mechanism of interaction of the sweet protein monellin with T1R2-T1R3 receptor. PMID:12706725
cysteine-rich region of T1R3 has a role in determining responses to intensely sweet proteins PMID:15299024
An immunohistochemistry study to determine whether and where T1R3 may be localized in the liver and pancreas. PMID:15585941
transmembrane domains of human T1R3 bind with lactisole to inhibit sweet taste PMID:15668251
Although T1R2-T1R3 is known to have multiple potential ligand-binding sites to receive a wide variety of sweeteners, the present study is apparently the first to identify the ATD of hT1R3 as a new sweetener-binding region. PMID:17499612
These results show that T1R2 and T1R3 receptors, in addition to their role in taste perception, may also have a role in intrahepatic cholangiocytes. PMID:17928076
Expressed in the sweet/umami gustatory pathways in taste receptor cells and trigeminal neural pathways in transgenic mice. PMID:18539481
The heteromeric G-protein-coupled receptor T1R2:T1R3 responds to a vast array of chemically diverse natural and artificial sweeteners. PMID:19083128
Variations in perception of umami taste correlated with variations in the human TAS1R3 gene. PMID:19587085