Phospho-NFKBIE (S22) Antibody

Code: CSB-PA020119

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Size:

50μg100μg

US$119

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Species Reactivity: Human,Mouse,Rat

Raised in: Rabbit

Application: WB, IHC, IF, ELISA

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Target Background

Product Details

Uniprot NO.

O00221

Target Names

NFKBIE

Alternative Names

I kappa B epsilon antibody; I-kappa-B-epsilon antibody; IkappaBepsilon antibody; IkB E antibody; IkB-E antibody; IkB-epsilon antibody; IKBE antibody; IKBE_HUMAN antibody; MGC72568 antibody; NF kappa B inhibitor epsilon antibody; NF kappa BIE antibody; NF-kappa-B inhibitor epsilon antibody; NF-kappa-BIE antibody; NFkappa BIE antibody; NFkappaB inhibitor epsilon antibody; NFKBIE antibody; Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor epsilon antibody; OTTHUMP00000016522 antibody; Slc35b2 antibody; solute carrier family 35; member B2 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthesized peptide derived from Human IκB-ε around the phosphorylation site of S22.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Tested Applications

WB, IHC, IF, ELISA

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Target Background

Function(From Uniprot)

Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes.

Gene References into Functions

identify NFKBIE aberrations as a common genetic event across B-cell malignancies and highlight NFKBIE deletions as a novel poor-prognostic marker in PMBL. PMID:27670424
We suggest that the impairment of NFKBIE gene function can reduce the uptake of methotrexate into cells, suggesting that the gene is an important factor for rheumatoid arthritis outcome PMID:26587663
A NFKBIE polymorphism was associated with increased risk of pneumococcal meningitis. PMID:26870821
results show that Gal-1 acts by inhibiting the stimulation of the LPS-induced IkappaBzeta expression, an NF-kappaB regulator involved in IL-6 gene transcription. PMID:26226212
Newly identified alterations included recurrent promoter mutations of NFKBIE, encoding NF-kappaB inhibitor varepsilon (IkappaBvarepsilon), in 14.5% of samples of desmoplastic melanoma PMID:26343386
Vitamin C forestalls cigarette smoke induced NF-kappaB activation in alveolar epithelial cells. PMID:23615073
we identified two gene loci associated with rheumatoid arthritis susceptibility- NFKBIE and RTKN2 PMID:23028356
Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon PMID:16769727
An NFKBIE SNP associated with susceptibility to pneumococcal disease but not pneumococcal empyema. PMID:17463416
Expression levels of GGT1 and possibly NFKBIE might be useful as biomarkers of genetic susceptibility to arsenite. PMID:17976673
Genomic mutation of the NFKBIE gene in primary Hodgkin/ Reed Sternberg cells PMID:14595753