PDZD3 Antibody, Biotin conjugated

Code: CSB-PA774807LD01HU
Size:
50μg
50μg100μg
US$166
Quantity:
Species Reactivity: Human
Raised in: Rabbit
Application: ELISA
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Product Details

Uniprot NO.
Target Names
PDZD3
Alternative Names
IKEPP antibody; Intestinal and kidney enriched PDZ protein antibody; Intestinal and kidney-enriched PDZ protein antibody; Na(+)/H(+) exchange regulatory cofactor NHE-RF4 antibody; Na/Pi cotransporter C terminal associated protein 2 antibody; Na/Pi cotransporter C-terminal-associated protein 2 antibody; NaPi-Cap2 antibody; Natrium-phosphate cotransporter IIa C-terminal-associated protein 2 antibody; NHERF-4 antibody; NHERF4 antibody; NHRF4_HUMAN antibody; PDZ domain containing 2 antibody; PDZ domain containing 3 antibody; PDZ domain containing protein 2 antibody; PDZ domain-containing protein 2 antibody; PDZ domain-containing protein 3 antibody; PDZD 3 antibody; Pdzd3 antibody; PDZK2 antibody; Protein DLNB27 antibody; Sodium-hydrogen exchanger regulatory factor 4 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Na(+)/H(+) exchange regulatory cofactor NHE-RF4 protein (42-291AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Tested Applications
ELISA
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Datasheet & COA

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Target Background

Function(From Uniprot)
Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation. Stimulates SLC9A3 activity in the presence of elevated calcium ions.
Gene References into Functions
  1. The NHERF4 is a novel modulator of luminal fluidity in the intestine by adjusting SLC26A3 expression and activity through a phosphorylation-dependent mechanism. PMID:22627094
  2. IKEPP was also found to be expressed in vascular endothelial cells where it co-localizes and complexes with the hIP PMID:22884631
  3. A novel PDZ protein regulates the activity of guanylyl cyclase C, the heat-stable enterotoxin receptor. PMID:11950846
  4. Regulation of NHE3 depends on the nature of the NHERF family member associating with NHE3 and the accompanying NHE3 complexes. PMID:19088451

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Subcellular Location
Cell membrane; Peripheral membrane protein. Cytoplasm.
Tissue Specificity
Expressed in kidney and the gastrointestinal tract. Not detected in brain, heart, skeletal muscle or cells of hematopoietic origin.
Database Links

HGNC: 19891

UNIGENE: Hs.374726

KEGG: hsa:79849

STRING: 9606.ENSP00000347742

OMIM: 607146

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