P4HTM Antibody

Code: CSB-PA878913LA01HU

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20μg50μg100μg

US$83

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Species Reactivity: Human

Raised in: Rabbit

Application: ELISA

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Target Background

Product Details

Uniprot NO.

Q9NXG6

Target Names

P4HTM

Alternative Names

EGLN4 antibody; HIF PH4 antibody; HIF Prolyl Hydroxylase 4 antibody; HIF prolyl hydroxylase PH 4 antibody; HIF prolyl hydroxylase PH4 antibody; HIF-PH4 antibody; HIF-prolyl hydroxylase 4 antibody; HIFPH4 antibody; HPH 4 antibody; HPH-4 antibody; Hypoxia inducible factor prolyl 4 hydroxylase antibody; Hypoxia-inducible factor prolyl hydroxylase 4 antibody; P4H with transmembrane domain antibody; P4H-TM antibody; P4htm antibody; P4HTM_HUMAN antibody; PH 4 antibody; PH4 antibody; PHD 4 antibody; Proline 4 hydroxylase antibody; prolyl 4-hydroxylase antibody; Transmembrane prolyl 4-hydroxylase antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Transmembrane prolyl 4-hydroxylase protein (82-563AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Tested Applications

ELISA

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Target Background

Function(From Uniprot)

Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.

Gene References into Functions

The results suggest that SESN2 increases degradation of HIF-1A via AMPK-PHD regulation that contributes to inhibition of in vitro and in vivo tumorigenesis. PMID:27840318
This review will expand our knowledge of biology of HIFs, PHDs, PHD inhibitors, and bone regeneration, and it may also aid the design of novel therapies for accelerating bone repair and regeneration or inhibiting bone tumours. [review] PMID:24895555
Results suggest that increased expression of prolyl hydroxylase (PH) might play an role in the physiology of uterine leiomyoma during the menstrual cycle. PMID:23241241
Data suggest that PH-4 is a novel hypoxia-inducible factor-prolyl hydroxylase that may be involved in the degradation of hypoxia-inducible transcription factors under normoxia. PMID:12163023
the longest and shortest isoenzymes have major transcripts encoding inactive polypeptides, which suggest novel regulation by alternative splicing. PMID:12788921
crystal structure of the peptide-substrate-binding domain PMID:15456751
This review summarizes recent progress in elucidating the molecular mechanisms of hypoxia-inducible factor (HIF)-1 activation, focusing on the role of oxygen-dependent asparaginyl hydroxylase in hypoxia signal transduction. PMID:16154531

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Subcellular Location

Endoplasmic reticulum membrane; Single-pass type II membrane protein.

Tissue Specificity

Widely expressed with highest levels in adult pancreas, heart, skeletal muscle, brain, placenta, kidney and adrenal gland. Expressed at lower levels in epiphyseal cartilage and in fibroblasts.

Database Links

HGNC: 28858

UNIGENE: Hs.654944

KEGG: hsa:54681

STRING: 9606.ENSP00000341422

OMIM: 614584

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