Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival. The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI. Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer. The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form.
Gene References into Functions
proinflammatory cytokines suppressed the TGFbetamediated expression of NGF in PDLderived fibroblasts through the inactivation of TGFbetainduced Smad2/3 and p38 MAPK signaling.PMID:29901090
Impairments in the extracellular maturation of proNGF are sufficient to cause a somatodendritic retrograde degeneration o fdegeneration of basal forebrain cholinergic neurons.PMID:29609077
McGill APP transgenic rats exhibit differential dysregulation in NGF and BDNF neurotrophins. At early stages, intraneuronal Abeta leads to significant reductions in BDNF mRNA expression, which correlate with learning and memory deficits. At later stages, deficits in the NGF metabolic pathway could explain the paradoxical upregulation of proNGF in the absence of changes in NGF mRNA.PMID:28865749
p75NTR is sufficient to mediate the modulation of myogenic cells differentiation by NGF in terms of structural, metabolic and functional changes.PMID:29202822
NGF protects GECs against IND-induced injury. Mitochondria are major targets of both INDO-induced injury and NGF afforded protection of GECs. TrkA expression in the mitochondria of GECs indicates that the protection afforded by NGF is partly mediated by its direct action on mitochondria. NGF prevents MMP depolarization and increases expression of IGF-1 protein in GECs.PMID:28843696
The results suggest that NGF is a prominent hyperalgesic mediator in the trigeminal system and plays a role in trigeminal neuropathic painPMID:27392124
Early and late behavioral changes in sciatic nerve injury may be modulated by nerve growth factor and substance P in ratsPMID:28685530
A higher level of nerve growth factor in the early days post-transvaginal mesh implantation is associated with a shorter voiding interval and a smaller bladder capacity, which represents abnormal lower urinary tract symptoms following transvaginal mesh implantation.PMID:27762470
Findings might aid in identifying effective treatment windows for nerve growth factor (NGF)-based strategies to counteract retinal and/or optic-nerve degeneration.PMID:28067793
The aim of our study was to investigate the influence of two mild stressors, acute and chronic exposure to forced swim (FS) or high-light open field (HL-OF), on neurons containing NGF.PMID:27978417
This work sheds light on the role of miR-132 in bladder overactivity, bladder hypertrophy, NGF signaling and expression of inflammatory mediators. Findings demonstrate that aberrant expression of NGF and miR-132 is involved in voiding dysfunctions.PMID:27789288
Data indicate the effects of vitamin B12 and omega-3 fatty acid supplementation across three consecutive generations on brain neurotrophins like brain derived neurotrophic factor (BDNF); nerve growth factor (NGF) and cognitive performance in the third generation male offspring.PMID:27569259
This study demonstrated that Age-dependent changes in the density of NGF-ir neurons in stressed rats are probably caused by ageing processes and they may point to dysregulation of excitatory control exerted by the amygdala.PMID:26724365
Data indicate that nerve growth factor precursors and nerve growth factor (ProNGF and NGF) and the downstream effector proteins play an important role in the growth, differentiation, and apoptosis of oligodendrocyte (OLG).PMID:26681653
NGF in the facet joint contributes to the development of injury-induced joint pain. Localized blocking of NGF signaling in the joint may provide potential treatment for joint pain.PMID:26521746
This study deminstrated that elevated NGF after peripheral nerve injury induces neurite sprouting and the formation of synapse-like structures within the contralateral DRG, leading to the development of chronic mirror-image pain.PMID:26121254
Results suggest the induction of NGF represents an adaptive response against immune-mediated neuroinflammation in the dorsal root ganglia and spinal cord that likely contributes to the experimental autoimmune encephalomyelitis attenuationPMID:25801841
elevation of plasma norepinephrine in neonatal colonic inflammation induces NGF expression in the gastric fundus.PMID:26608656
NGF acts directly on photoreceptors survival and prevents photoreceptor degeneration.PMID:25897972
Identify nerve growth factor as a binding partner for MOG and demonstrate that this interaction is capable of sequestering NGF from TrkA-expressing neurons to modulate axon growth and survival.PMID:26347141
Ginger extract has a synaptogenic effect via NGF-induced ERK/CREB activation, resulting in memory enhancement.PMID:25049196
Chronic heart failure impairs the expression of nerve growth factor in the sympathetic and sensory nerves.PMID:24913185
Vibration significantly increases total-NGF mRNA in interverterbal discs. Protein expression of BDNF increases by nearly 10-fold, especially in the inner annulus fibrosus and nucleus pulposus.PMID:24921856
NGF exhibits anti-oxidative and hepatoprotective effects and is suggested to be therapeutically applicable in treating cholestatic liver diseases.PMID:25397406
Activation of microtubule dynamics increases neuronal growth via the NGF- and Galpha s-mediated signaling pathways.PMID:25691569
NGF was increased 12, 24, and 48 hours in hippocampus after sepsis inductionPMID:24978930
Findings revealed that NGF may play a pivotal role of anti-apoptosis in spinal cord neurons through retrograde transport of NF-kappaB in Schwann cells following sciatic nerve injury in ratsPMID:24620979
Maternal separation decreased NGF levels in the hippocampus which was reversed with methamphetamine.PMID:24407463
the level of NGF expression did not display a meaningful change throughout the immobilization periodPMID:24154957
Spinal nerve afferents are important in sustaining and up-regulating the expression of NGF in the sensory neurons innervating the heart in acute myocardial infarction.PMID:24508054
NGF played an important role in the activation of Akt and subsequent up-regulation of BDNF in the sensory neurons in visceral inflammation such as cystitis.PMID:24303055
The temporal mismatch in behaviour, skin [NGF] and phenotypic changes in sensory nerve fibres indicate that increased [NGF] does not cause hyperalgesia after partial mental nerve injury.PMID:24380503
Using gene expression as a functional read-out, our data demonstrate that the relative availability of NGF and proNGF in vivo might modulate the biological outcome of these ligands.PMID:24713110
The synergistic effects of grafting both NGF and GRGD ligands to PCL-CS scaffolds on the growth and differentiation of PC12 cells provide a new biomaterial for neural tissue engineering.PMID:23468336
Denervation causes age-dependent increases in NGF in the VP, which is a potential mechanism by which the autonomic nervous system may regulate prostate growth and lead to BPH/LUTSPMID:23872662
proBDNF accumulated in the hippocampus of aged rats.PMID:23255148
The effects of acute and chronic administration of branched-chain amino acids on protein levels and mRNA expression of nerve growth factor, was investigated.PMID:23559405
Suggest that nerve growth factor, which is elevated in the failing human heart, causes hypertrophy of neurons in cardiac ganglia.PMID:23959444
Hyperosmolarity induces apoptosis of pHCECs by activating JNK signaling.PMID:24327613
Environmental enrichment improves memory and increases nerve growth factor (NGF) concentration in the dentate gyrus.PMID:23460346
NGF contributes to the repair of nerve tissue and improves pain-related behavior after inferior alveolar nerve injury.PMID:23190308
Long-term casting induced heat hyperalgesia, and up-regulation and phenotypic change of NGF in dorsal root gangliaPMID:23234417
Data indicate that nerve growth factor (NGF) mRNA levels changed significantly during Leydig-cell regeneration in vivo.PMID:23743199
Upregulation of NGF in the amygdala promotes behavior of opioid reward and increases sensitivity to subsequent opioids.PMID:22871918
This study suggests that application of hADSCs with NGF-hydrogel on the CN might be a promising treatment for postprostatectomy ED.PMID:22834730
NGF increased expression of ASIC3 in DRG neurons.PMID:22744968
[REVIEW] Neuropathies and clinical presentations result from disruption of NGF signalling in hereditary sensory autonomic neuropathies (HSAN) type IV and HSAN type V.PMID:23157347
NGF gene expression is elevated during the whole course of cerebral concussion, especially in the early phase.PMID:12857442
There were much more Ngf-immunoreactive nerve cells expressed in the dorsal horn in sciatic nerve cryoneurolysis rats with hyperalgesia.PMID:22580175
Show
More
Hide
All
Subcellular Location
Secreted. Endosome lumen.
Protein Families
NGF-beta family
Tissue Specificity
Detected in the granule and pyramidal cell layer in the hippocampus.