Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Target-derived survival factor for peripheral sensory sympathetic neurons.
Gene References into Functions
Elevated intra-amniotic levels of docosahexaenoic acid and arachidonic acid in the mid-trimester are correlated with increased NT4 concentrations.PMID:24607879
The NTF4 variants p.Gly157Ala and p.Ala182Val have been shown to be functional mutations, occurring in 2 of a total of 720 Chinese primary open-angle glaucoma patients.PMID:22815630
NT-4/5 expression is associated with atrophy of the brain-parenchymal fraction measured by magnetic resonance imaging methods in patients with relapsing-remitting multiple sclerosis.PMID:22036954
Suggest that a dysregulated TrkB/NT4/5 axis may contribute to several of the pathological lesions associated with pulmonary fibrosis, including type 2 alveolar cell hyperplasia and the proliferation of fibroblasts.PMID:21330466
neurotrophin 4 contributes to breast cancer cell survival and can serve as prospective target to inhibit tumor growthPMID:21350004
In vitro follicular assembly is significantly increased in fetal ovaries cultured with NT-4.PMID:20447632
Identification of a single mutation in our study suggests that NTF4 mutations are a rare cause of primary open-angle glaucoma (0.6%, 95%CI 0.02%-3.16%) in Chinese people.PMID:20806036
present data indicate a lack of involvement of variations in NTF4, VAV2, and VAV3 with glaucoma pathogenesis in an Indian population.PMID:20463313
Expression of human NTF4 was unchanged during gestation in the developping ovary.PMID:20175187
No evidence of association of heterozygous NTF4 mutations in patients with primary open-angle glaucoma.PMID:20215012
A mechanism to understand the defect associated with variant BDNF and provide a framework two ligands for BDNF and NT-4.PMID:15987945
Re-expression of the p75NTR appears to partially reverse de-differentiation of prostate cancer cells by up-regulating the expression of CRABPI for localized sequestration of retinoids.PMID:16316409
Results revealed the expression of NT-4/5 mainly in oocytes and, in a minority of samples, also in the granulosa cells (GCs).PMID:16648150
These novel data demonstrate that neurotrophins influence ASM [Ca(2+)](i) and force regulation and suggest a potential role for neurotrophins in airway diseasesPMID:16648236
Neurotrophin 4/5 plays a role in the proliferation and differentiation of periodontal ligament cells.PMID:18980528
Data show that the levels of NT-4/5 levels are significantly higher in bipolar disorder patients than in controlsNT-4/5. immunocontent alterations in bipolar disorder.PMID:19081579
NTF4 mutations impair neurotrophin-4 signaling in patients with primary open-angle glaucoma and lead to decreased activation of TrkBPMID:19765683
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Subcellular Location
Secreted.
Protein Families
NGF-beta family
Tissue Specificity
Highest levels in prostate, lower levels in thymus, placenta, and skeletal muscle. Expressed in embryonic and adult tissues.