ME2 Antibody, FITC conjugated

Code: CSB-PA013633HC01HU

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Size:

50μg100μg

US$166

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Species Reactivity: Human

Raised in: Rabbit

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Target Background

Product Details

Uniprot NO.

P23368

Target Names

ME2

Alternative Names

Malate dehydrogenase antibody; Malic enzyme 2 antibody; Malic enzyme 2 mitochondrial antibody; Malic enzyme 2 NAD(+) dependent mitochondrial antibody; Malic enzyme mitochondrial antibody; Malic enzyme NAD(+) dependent mitochondrial antibody; MAOM_HUMAN antibody; ME 2 antibody; ME2 antibody; mitochondrial antibody; NAD dependent malic enzyme mitochondrial antibody; NAD ME antibody; NAD-dependent malic enzyme antibody; NAD-ME antibody; ODS1 antibody; Pyruvic malic carboxylase antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human NAD-dependent malic enzyme, mitochondrial protein (296-424AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

FITC

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Gene References into Functions

ME2 was involved in glioblastoma multiforme growth, invasion, migration, Reactive oxygen species and ATP production. PMID:27166188
deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer PMID:28099419
Data indicate that malic enzyme 2 knockdown impacts phosphatidylinositol 3-kinases/proto-oncogene protein akt (PI3K/AKT) signaling. PMID:24957098
ME2 might be an important factor in melanoma progression and a novel biomarker of invasion. PMID:25202825
Three SNP alleles in BRD2, Cx-36, and ME2 and microdeletions in 15q13.3, 15q11.2, and 16p13.11 also contribute risk to juvenile myclonic epilepsy. PMID:23756480
Depletion of malic enzyme 2 induced erythroid differentiation in human erythroleukemia cells. PMID:20824065
An ME2-centered nine-SNP haplotype, when present homozygously, increases the risk for IGE (odds ratio 6.1; 95% confidence interval 2.9-12.7) compared with any other genotype PMID:15532013
Site directed mutagenesis was used to detrmine which amino acids in the active site of human mitochondrial NAD+-dependent malic enzyme are necessary for the inhibitory effects of ATP. PMID:16171388
These findings provide a molecular rationale for the role of hS14 in TR-dependent transcriptional activation of the expression of specific genes. PMID:17418816
Schizophrenic subjects are identified with mitochondrial genes involved in oxidative metabolism as showing consistently decreased expression, including ME2. PMID:17638511
Single nucleotide polymorphism in ME2 gene is associated with acute lymphoblastic leukemia. PMID:19066393
ME2 activity in Islets of Langerhans cells was measured by a spectrophotometric enzyme assay by utilizing the distinct kinetic properties. PMID:19691144