KCNMB4 Antibody

Code: CSB-PA255042

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Size:

50μl100μl

US$166

Quantity:

Species Reactivity: Human,Mouse,Rat

Raised in: Rabbit

Application: ELISA,WB,IHC

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Target Background

Product Details

Uniprot NO.

Q86W47

Target Names

KCNMB4

Alternative Names

BK channel subunit beta 4 antibody; BK channel subunit beta-4 antibody; BKbeta4 antibody; Calcium activated potassium channel beta 4 subunit antibody; Calcium activated potassium channel subfamily M subunit beta 4 antibody; Calcium activated potassium channel subunit beta 4 antibody; Calcium-activated potassium channel antibody; Calcium-activated potassium channel subunit beta-4 antibody; Charybdotoxin receptor subunit beta 4 antibody; Charybdotoxin receptor subunit beta-4 antibody; Hbeta4 antibody; K(VCA)beta 4 antibody; K(VCA)beta-4 antibody; KCMB4_HUMAN antibody; KCNMB 4 antibody; Kcnmb4 antibody; Large conductance calcium dependent potassium ion channel beta 4 subunit antibody; Maxi K channel subunit beta 4 antibody; Maxi K channel subunit beta-4 antibody; Potassium large conductance calcium activated channel subfamily M beta member 4 antibody; Slo beta 4 antibody; Slo-beta-4 antibody; subfamily M subunit beta-4 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthetic peptide of Human KCNMB4

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Tested Applications

ELISA,WB,IHC

Protocols

ELISA Protocol Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA255042(KCNMB4 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA255042(KCNMB4 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: CSB-PA255042(KCNMB4 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute

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Target Background

Function(From Uniprot)

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations.

Gene References into Functions

Two recurrent fusion genes associated with the 12q locus, LRP1-SNRNP25 and KCNMB4-CCND3, were by RT-PCR, Sanger sequencing and FISH, and were found to be osteosarcoma specific in a validation cohort of 240 other sarcomas. PMID:25300797
Recombinant martentoxin selectively blocks KCNMA1/KCNMB4 channels. PMID:24759175
BK channel beta4 subunit influences sensitivity and tolerance to alcohol by altering its response to kinases PMID:25190810
Study shows that beta4 subunit of the MaxiK channel has no potential endocytic signal and 2 specific amino acids in the functional basic motif retention/retrieval trafficking signal at the C-terminus may play a role in controlling cellular excitability PMID:24486049
our data suggest that the rs398702 variant in the KCNMB4 gene is unlikely to influence significantly the risk of developing mesial temporal lobe epilepsy or its severity PMID:23623847
These results suggest that fast-gating, type I BK channels lacking beta4 can increase neuronal excitability in response to reduced phosphatase activity and activation of calcium channels. PMID:21848922
Structural basis for toxin resistance of beta4-associated calcium-activated potassium (BK) channels PMID:18559348
The beta4 subunit controls ethanol tolerance at the molecular, cellular, and behavioral levels, and could determine individual differences in alcohol abuse and alcoholism, as well as represent a therapeutic target for alcoholism. PMID:18981408
results argue that, for native mouse Slo3 channels, the beta4 subunit must be considered as a potential interaction partner and, furthermore, that KCNMB subunits may have functions unrelated to regulation of the Slo1 alpha subunit PMID:19578543

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Subcellular Location

Membrane; Multi-pass membrane protein.

Protein Families

KCNMB (TC 8.A.14.1) family, KCNMB4 subfamily

Tissue Specificity

Predominantly expressed in brain. In brain, it is expressed in the cerebellum, cerebral cortex, medulla, spinal cord, occipital pole, frontal lobe, temporal lobe, putamen, amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra and thala

Database Links

HGNC: 6289

UNIGENE: Hs.525529

KEGG: hsa:27345

STRING: 9606.ENSP00000258111

OMIM: 605223

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