IL22RA2 Antibody

Code: CSB-PA850247ESR1HU

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Size:

20μl50μl100μl

US$83

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Species Reactivity: Human

Raised in: Rabbit

Application: ELISA, IHC

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Target Background

Product Details

Uniprot NO.

Q969J5

Target Names

IL22RA2

Alternative Names

IL 22BP antibody; IL 22RA2 antibody; IL22RA2 antibody; Class II cytokine receptor antibody; CRF2 10 antibody; CRF2 S1 antibody; CRF2-10 antibody; CRF2-S1 antibody; CRF2X antibody; Cytokine receptor class II member 10 antibody; Cytokine receptor class-II member 10 antibody; Cytokine receptor family 2 member 10 antibody; Cytokine receptor family type 2 antibody; Cytokine receptor family type 2 soluble 1 antibody; I22R2_HUMAN antibody; IL 22 receptor subunit alpha 2 antibody; IL 22R alpha 2 antibody; IL-22 receptor subunit alpha-2 antibody; IL-22BP antibody; IL-22R-alpha-2 antibody; IL-22RA2 antibody; IL22 RA2 antibody; IL22BP antibody; IL22R alpha 2 antibody; Il22ra2 antibody; Interleukin 22 binding protein antibody; Interleukin 22 Receptor alpha 2 antibody; Interleukin-22 receptor subunit alpha-2 antibody; Interleukin-22-binding protein antibody; MGC150509 antibody; MGC150510 antibody; soluble 1 antibody; ZcytoR16 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Interleukin-22 receptor subunit alpha-2 protein (22-231AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA850247ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA850247ESR1HU at dilution of 1:100

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Target Background

Function(From Uniprot)

Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.; Isoform 1 may play a role in establishing and maintaining successful pregnancy.

Gene References into Functions

expression higher in the epidermal compartment of the skin in comparison with dermis in both healthy skin and psoriasis skin PMID:27676439
suggest that the human IL-22BP isoforms have distinct spatial and temporal roles and coordinately fine-tune IL-22-dependent STAT3 responses in tissues as a type of rheostat. PMID:27678220
thia study shows shows that nonaffected skin of psoriasis patients displays lower expression of IL-22BP than skin of healthy controls, and that the strong IL-22 increase in lesional psoriatic skin is accompanied by a moderate induction of IL-22BP PMID:28356382
The deletion of IFNGR1 causes complete IFN-gammaR1 deficiency. Despite the deletion ending very close to the IL22RA2 gene, it does not appear to affect IL22RA2 transcription. PMID:26931784
IL-22BP is produced by eosinophils in the gut and blocks IL-22 protective actions in colitis. PMID:26329427
Through a combined approach including genetic and immunological investigation in an animal model and large-scale association studies of patients with multiple sclerosis (MS), IL-22RA2 is established as an MS risk gene. PMID:21041731
The IL-22R and IL-10R2 binding sites are juxtaposed on adjacent IL-22 surfaces contributed mostly by helices A, D, and F and loop AB. PMID:18675824
Crystallization and preliminary X-ray diffraction results of the IL-22-IL-22 binding protein (IL-22BP) complex are described. PMID:19193995
Polymorphisms in IL22RA1 are associated with severe CRS. PMID:19393422

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Subcellular Location

Secreted.

Protein Families

Type II cytokine receptor family

Tissue Specificity

Expressed in placenta, spleen, breast, skin and lung. Also detected in intestinal tract, testis, brain, heart and thymus. No expression found in prostate, bladder, kidney, ovary, muscle, bone marrow, liver and uterus. Isoform 1 is expressed only in placen

Database Links

HGNC: 14901

UNIGENE: Hs.126891

KEGG: hsa:116379

STRING: 9606.ENSP00000296980

OMIM: 606648

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