GPR65 Antibody

Code: CSB-PA732036

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Size:

50μl100μl

US$166

Quantity:

Species Reactivity: Human

Raised in: Rabbit

Application: ELISA,IHC

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Product Details
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Target Background

Product Details

Uniprot NO.

Q8IYL9

Target Names

GPR65

Alternative Names

GPR65; TDAG8; Psychosine receptor; G-protein coupled receptor 65; T-cell death-associated gene 8 protein

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide of Human GPR65

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Tested Applications

ELISA,IHC

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA732036(GPR65 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: ×200)

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function(From Uniprot)

Receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids. Plays a role in immune response by maintaining lysosome function and supporting phagocytosis-mediated intracellular bacteria clearance. May have a role in activation-induced cell death or differentiation of T-cells.

Gene References into Functions

TDAG8 functions as a contextual tumor suppressor down-regulated in hematological malignancies. PMID:29017562
Study results suggest greater T cell death associated gene-8 (TDAG8) expression in patients with panic disorder compared to healthy subjects, and directly link TDAG8 expression and the severity of the panic disorder symptoms PMID:28736033
this study establishes a role for GPR65 in inflammatory bowel disease susceptibility and identify lysosomal dysfunction as a potentially causative element in pathogenesis PMID:27287411
TDAG8 expression is decreased by more than 50%. PMID:24152439
GPR65 is a regulator upstream of MMP3, which is regulated by proton-sensing G-protein-coupled receptors PMID:23707809
Acidosis promotes Bcl-2 family-mediated evasion of apoptosis: involvement of acid-sensing G protein-coupled receptor Gpr65 signaling to Mek/Erk. PMID:22685289
Data suggest that one physiological function of TDAG8 is negative regulation of inflammation by inhibiting production of pro-inflammatory cytokines in T-lymphocytes and macrophages. PMID:22445881
These results support the hypothesis that TDAG8 enhances tumor development by promoting adaptation to the acidic environment to enhance cell survival/proliferation. PMID:20855608
GPR4 and TDAG8 overexpression in human tumors plays a role in driving or maintaining tumor formation PMID:15221007
TDAG8 is one of the proton-sensing GPCRs coupling to adenylyl cyclase and psychosine, and its related lysosphingolipids behave as if they were antagonists against protein-sensing receptors, including TDAG8, GPR4, and OGR1. PMID:15326175
TDAG8 may play biological roles in immune response and cellular transformation under conditions accompanying tissue acidosis. PMID:15618224
Expression of TDAG8 by immune cells may regulate responses in acidic microenvironments. PMID:15665078
At least partly, TDGA8 mediates extracellular acidification-induced inhibition of proinflammatory cytokine production through the Gs protein/cyclic AMP-dependent protein kinase A signaling pathway in transgenic mouse macrophages. PMID:19234222