GNAZ Antibody

CSB-PA009601LA01HU

Rate （5.0）
Review （1）
Citation （1）

Size:

20μg50μg100μg

US$83

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Species Reactivity: Human

Raised in: Rabbit

Application: ELISA, IHC, IF

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Target Background

Product Details

Uniprot NO.

P19086

Target Names

GNAZ

Alternative Names

G(x) alpha chain antibody; GNAZ antibody; GNAZ_HUMAN antibody; Guanine nucleotide-binding protein G(z) subunit alpha antibody; Gz-alpha antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Guanine nucleotide-binding protein G(z) subunit alpha protein (3-140AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Protocols

ELISA Protocol Immunohistochemistry (IHC) Protocol Immunofluorescence (IF) Protocol

Datasheet & COA

Antibody FAQs

Images

Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA009601LA01HU at dilution of 1:100
Immunofluorescent analysis of Hela cells using CSB-PA009601LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Description

Customer Reviews and Q&A

■ Customer Reviews

Average Rating:

5.0 - 1 reviews

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Sample type: tissues

Review: describe

By Anonymous

Citations

Blue light exposure collapses the inner blood-retinal barrier by accelerating endothelial CLDN5 degradation through the disturbance of GNAZ and the activation of ADAM17 YJ Chan,/,2023

Target Background

Function

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

Gene References into Functions

GNAZ mutations are associated with melanoma. PMID:20424519
cGMP-phosphodiesterase 6 can be activated by another cancer-retina antigen, transducin, through Wnt5a-Frizzled-2 cascade, which leads to a lowering of cGMP and an increase in intracellular calcium mobilization. PMID:19946729
findings suggest that Galphaz signals may attenuate Rho-induced stimulation of SRF-mediated transcription PMID:15326221

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Subcellular Location

Membrane; Lipid-anchor.

Protein Families

G-alpha family, G(i/o/t/z) subfamily

Database Links

HGNC: 4395

UNIGENE: Hs.584760

KEGG: hsa:2781

STRING: 9606.ENSP00000248996

OMIM: 139160

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