FCRL5 Antibody, FITC conjugated

Code: CSB-PA853494LC01HU

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Size:

50μl100μl

US$166

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Species Reactivity: Human

Raised in: Rabbit

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Target Background

Product Details

Uniprot NO.

Q96RD9

Target Names

FCRL5

Alternative Names

BXMAS1 antibody; CD307 antigen antibody; CD307e antibody; Fc receptor homolog 5 antibody; Fc receptor like 5 antibody; Fc receptor-like protein 5 antibody; FcR-like protein 5 antibody; FcRH5 antibody; FcRL5 antibody; FCRL5_HUMAN antibody; Immune receptor translocation-associated protein 2 antibody; Immunoglobulin receptor translocation associated gene 2 protein antibody; Immunoglobulin superfamily receptor translocation associated gene 2 protein antibody; IRTA2 antibody; UNQ503/PRO820 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Fc receptor-like protein 5 protein (419-553AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

FITC

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-4 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function(From Uniprot)

May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells.

Gene References into Functions

based on FCRL5 binding, we can discern distinct changes in the IgG2 molecule, including the disulfide isoform structure and charge variants related to deamidation. Since both IgG2 deamidation and conversion of disulfide isoforms occur in vivo, these findings elucidate the biological FCRL5 ligand. PMID:29101848
we found that FCRL5 expression is induced specifically upon BCR stimulation and dissected the molecular mechanism PMID:27065451
this study revealed that the FCRL5+ tissue-like memory subset responds poorly to multiple stimuli compared with the FCRL5- subset, as reflected by reduced calcium mobilization and blunted cell proliferation PMID:27076679
Data suggest that expression of FCRL5 (but not FCRL4) on surface of atypical (perhaps dysfunctional) memory B-Lymphocytes is up-regulated by exposure to Plasmodium falciparum antigens in subjects in Uganda where malaria is endemic. PMID:25993340
FCRL5 is a new type of receptor that recognizes intact IgG, possibly enabling B cells to sense Ig quality. Recognition of undamaged IgG molecules by FCRL5 could allow B cells to engage recently produced Abs. PMID:23616577
FcRL5 binds all immunoglobulin (Ig)G isotypes with varied efficiency. PMID:22491254
Enhanced proliferation and downstream isotype expression upon FCRL5 stimulation could reflect a physiological role for FCRL5 in the expansion and development of antigen-primed B cells. PMID:22028333
Three of the FCRL5 tag SNPs, rs6667109, rs3811035 and rs6692977 showed association with Graves' disease. association with FCRL5 was secondary to linkage disequilibrium with the FCRL3, rs11264798 and rs10489678 SNPs. PMID:20626413
Characterization and comparison of the structure and B-cell expression pattern of the entire family of IRTA genes, which includes 5 members contiguously located on chromosome. PMID:11929751
IRTA2 is expressed on the surface of human lymphoma cell lines and hairy cell leukemia cells PMID:15671532
results identify FcRH5 as a novel, direct target of EBNA2 that may contribute to the development of Epstein-Barr virus-associated tumors PMID:16439682
IRTA2/FcRH5 may have a role in hairy cell leukemia PMID:16681430
Down-regulation of FCRL5 is associated with acute lymphoblastic leukemia. PMID:18802695
Single-nucleotide polymorphism in the FCRL5 gene and HLA-B27 is associated with ankylosing spondylitis. PMID:19775371

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Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Tissue Specificity

Expressed in marginal zone B-cells, immunoblasts, tonsillar germinal center centrocytes and in the intraepithelial and interfollicular regions of the tonsil. Expressed in many lymphoma cell lines and on hairy cell leukemia cells. Isoform 1, isoform 3, iso

Database Links

HGNC: 18508

UNIGENE: Hs.415950

KEGG: hsa:83416

STRING: 9606.ENSP00000354691

OMIM: 605877

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