EZH1 Antibody

Code: CSB-PA852913DSR2HU

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20μl50μl100μl

US$83

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Species Reactivity: Human, Mouse

Raised in: Rabbit

Application: ELISA, WB, IHC

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Target Background

Product Details

Uniprot NO.

Q92800

Target Names

EZH1

Alternative Names

Enhancer of zeste homolog 1 (Drosophila) antibody; Enhancer of zeste homolog 1 antibody; ENX-2 antibody; ENX2 antibody; Ezh1 antibody; EZH1_HUMAN antibody; Histone-lysine N-methyltransferase EZH1 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Histone-lysine N-methyltransferase EZH1 protein (160-280AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Western blot
All lanes: Histone-lysine N-methyltransferase EZH1 antibody at 4μg/ml
Lane 1: Hela whole cell lysate
Lane 2: HL60 whole cell lysate
Lane 3: Mouse gonad tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 86, 87, 81, 77, 69 kDa
Observed band size: 86 kDa
Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA852913DSR2HU at dilution of 1:100

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Target Background

Function(From Uniprot)

Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.

Gene References into Functions

identification of EZH1 as a repressor of haematopoietic multipotency in the early mammalian embryo PMID:29342143
pVHL loss causes the transcriptional activation of hypoxia-inducible factor (HIF) target genes, including many genes that encode histone lysine demethylases. PMID:28701475
Data show that embryonic stem cells with deletion of EZH1 or EZH2 fail to differentiate into ectoderm lineages. PMID:28939884
Expression of the EZH2 homolog EZH1 is reduced in EZH2-deficient CML LICs, creating a scenario resembling complete loss of PRC2. EZH2 dependence of CML LICs raises prospects for improved therapy of TKI-resistant CML and/or eradication of disease by addition of EZH2 inhibitors PMID:27630126
a hot-spot mutation in EZH1 is the second most frequent genetic alteration in autonomous thyroid adenomas; the association between EZH1 and TSHR mutations suggests a 2-hit model for the pathogenesis of these tumors, whereby constitutive activation of the cAMP pathway and EZH1 mutations cooperate to induce the hyperproliferation of thyroid cells PMID:27500488
EZH1, SUZ12 and UXT work synergistically to regulate pathway activation in the nucleus. PMID:27127229
The authors report a novel PRC2-Ezh1 function that utilizes Ezh1beta as an adaptive stress sensor in the cytoplasm, thus allowing postmitotic cells to maintain tissue integrity in response to environmental changes. PMID:28346433
These evidences suggest that EZH2 and EZH1 are important in the counter-balancing mechanisms controlling proliferation/resting of lymphoid cells. The disruption of the balanced EZH2/EZH1 ratio may play important roles in the pathogenesis of lymphomas PMID:27311868
The related enzymatic subunits EZH1 and EZH2 undergo an expression switch during blood cell development. PMID:25578878
EZH1 maintains repressive chromatin through different mechanisms. PMID:19026781