EZH1 Antibody

1. identification of EZH1 as a repressor of haematopoietic multipotency in the early mammalian embryo PMID:29342143
2. pVHL loss causes the transcriptional activation of hypoxia-inducible factor (HIF) target genes, including many genes that encode histone lysine demethylases. PMID:28701475
3. Data show that embryonic stem cells with deletion of EZH1 or EZH2 fail to differentiate into ectoderm lineages. PMID:28939884
4. Expression of the EZH2 homolog EZH1 is reduced in EZH2-deficient CML LICs, creating a scenario resembling complete loss of PRC2. EZH2 dependence of CML LICs raises prospects for improved therapy of TKI-resistant CML and/or eradication of disease by addition of EZH2 inhibitors PMID:27630126
5. a hot-spot mutation in EZH1 is the second most frequent genetic alteration in autonomous thyroid adenomas; the association between EZH1 and TSHR mutations suggests a 2-hit model for the pathogenesis of these tumors, whereby constitutive activation of the cAMP pathway and EZH1 mutations cooperate to induce the hyperproliferation of thyroid cells PMID:27500488
6. EZH1, SUZ12 and UXT work synergistically to regulate pathway activation in the nucleus. PMID:27127229
7. The authors report a novel PRC2-Ezh1 function that utilizes Ezh1beta as an adaptive stress sensor in the cytoplasm, thus allowing postmitotic cells to maintain tissue integrity in response to environmental changes. PMID:28346433
8. These evidences suggest that EZH2 and EZH1 are important in the counter-balancing mechanisms controlling proliferation/resting of lymphoid cells. The disruption of the balanced EZH2/EZH1 ratio may play important roles in the pathogenesis of lymphomas PMID:27311868
9. The related enzymatic subunits EZH1 and EZH2 undergo an expression switch during blood cell development. PMID:25578878
10. EZH1 maintains repressive chromatin through different mechanisms. PMID:19026781

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HGNC: 3526

UNIGENE: Hs.194669

KEGG: hsa:2145

STRING: 9606.ENSP00000404658

OMIM: 601674