ENPEP Antibody, Biotin conjugated

Code: CSB-PA14759D0Rb

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50μg100μg

US$166

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Species Reactivity: Human

Raised in: Rabbit

Application: ELISA

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Target Background

Product Details

Uniprot NO.

Q07075

Target Names

ENPEP

Alternative Names

Aminopeptidase A antibody; AMPE_HUMAN antibody; AP-A antibody; APA antibody; bp-1 antibody; bp1 antibody; CD249 antibody; Differentiation antigen gp160 antibody; EAP antibody; Enpep antibody; Glutamyl aminopeptidase (aminopeptidase A) antibody; Glutamyl aminopeptidase antibody; Gp160 antibody; Ly51 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Glutamyl aminopeptidase protein (719-949AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Biotin

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Tested Applications

ELISA

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function(From Uniprot)

Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II.

Gene References into Functions

We suggest that APA enzymatic activity affects tumor initiation and cancer malignancy in a TWIST-dependent manner PMID:28177885
The substrate Angiotensin II, the enzymes aminopeptidases-A, B, M as well as IRAP were detected in the jejunal mucosa. PMID:26311161
This study suggests a role for GAP in the neoplastic development of renal tumours and provides additional data for considering the activity and expression of this enzyme of interest in the diagnosis and prognosis of renal neoplasms. PMID:24885240
These results explain the calcium-modulated substrate specificity of APA in central hypertension regulation PMID:23888046
There was no significant alteration in plasma APA activity in the patients with Chagas disease or dilated cardiomyopathies, as compared with that in health controls PMID:21697726
Rieger syndrome with microdeletions including only the PITX2 and ENPEP (glutamyl aminopeptidase) genes. PMID:17850355
Data show that APA appears to be an essential enzyme in the control of blood pressure via degradation of Angiotensin II. PMID:17990103
Data show that aminopeptidase A (APA) plays important roles in the regulation of blood pressure under both the physiological and pathological conditions. PMID:17999179
Data show that brain aminopeptidases act upon Ang I, Ang II and Ang III in order to activate brain AT(1) receptors. PMID:18188697
rare and common variation in ENPEP may contribute to the development of renal and hypertensive disorders and warrants further study PMID:18206321
The presence of APA in several human brain nuclei sensitive to angiotensins and involved in blood pressure regulation suggests that APA in humans is an integral component of the brain renin angiotensin system. PMID:18410507
A novel nonsense polymorphism in the aminopeptidase-a gene was associated with hypertension among postmenopausal women, and those with marginal calcium and vitamin D intake. PMID:18550936
Angiotensin III and aminopeptidase A and N, related converting enzymes, contribute to cell proliferation of prostate cancer and may be implicated in cancer progression. PMID:18677709
Over-expressed APA drastically reduces, in a calcium dependent manner, full-length-Abeta but not amyloid-beta precursor protein (APP) intracellular domain in a cell-free model of Abeta production. PMID:19187443
The activity of glutamyl aminopeptidase was significally increased in head and neck squamous cell carcinoma tissue. PMID:19373777

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Subcellular Location

Cell membrane; Single-pass type II membrane protein.

Protein Families

Peptidase M1 family

Tissue Specificity

Expressed in choriocarcinoma cancer cell lines (at protein level). Expressed by epithelial cells of the proximal tubule cells and the glomerulus of the nephron. Also found in a variety of other tissues.

Database Links

HGNC: 3355

UNIGENE: Hs.435765

KEGG: hsa:2028

STRING: 9606.ENSP00000265162

OMIM: 138297

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