ENOX2 Antibody

Code: CSB-PA007677ESR1HU

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20μl50μl100μl

US$83

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Species Reactivity: Human

Raised in: Rabbit

Application: ELISA, IHC

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Target Background

Product Details

Uniprot NO.

Q16206

Target Names

ENOX2

Alternative Names

APK1 antibody; APK1 antigen antibody; COVA1 antibody; Cytosolic ovarian carcinoma antigen 1 antibody; Ecto NOX disulfide thiol exchanger 2 antibody; ENOX 2 antibody; ENOX2 antibody; ENOX2_HUMAN antibody; OTTHUMP00000024021 antibody; OTTHUMP00000024022 antibody; Protein disulfide-thiol oxidoreductase antibody; tNOX antibody; Tumor associated hydroquinone oxidase antibody; Tumor-associated hydroquinone oxidase antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Ecto-NOX disulfide-thiol exchanger 2 protein (411-610AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA007677ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA007677ESR1HU at dilution of 1:100

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Target Background

Function(From Uniprot)

May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock.

Gene References into Functions

The tumor-associated NADH oxidase (tNOX)-mediated modulation of the NAD+ concentration and SIRT1 are involved in oxaliplatin-induced apoptosis. PMID:28122359
These findings not only shed light on the molecular mechanism of the anticancer properties of capsaicin, but also the transcription regulation of tNOX expression that may potentially explain how POU3F2 is associated with tumorigenesis. PMID:27271588
The findings support a role for arNOX as a major source of oxidative damage leading to cross-linking of skin proteins. PMID:24906676
The results suggest that phosphorylation of serine-504 by PKCdelta modulates the biological function of tNOX. PMID:22659163
this result suggests that hnRNP F directs formation of the exon 4 minus variant of ENOX2. PMID:21625959
increased NADH levels resulting from ENOX2 inhibition result in decreased prosurvival sphingosine-1-phosphate and increased proapoptotic ceramide, both of which may be important to initiation of the ENOX2 inhibitor-induced apoptotic cascade. PMID:21571040
ENOX2 is a dimeric protein containing 4 coppers/dimer capable of carrying out concerted four electron transfers from NADH or ubiquinol to molecular oxygen as required to form water. PMID:20922471
arNOX activity correlates with age and reaches a maximum at about age 65 in males and 55 in females. PMID:20345278
Enhanced arNOX activity correlates with age and with oxidative changes contributing to skin aging. PMID:19734125
tNOX is both necessary and sufficient for the cellular anticancer activities attributed to both EGCg and capsaicin. *tNOX enzyme PMID:15706060
results indicate that shRNA targeting of tNOX inhibits the growth of cervical cancer cells, and reduces cell migration via a decrease in the membrane association of Rac. PMID:18023414
A relationship of tNOX to unregulated growth of cancer cells was provided by data where growth of HeLa cells was inhibited by transfection with the exon 5 antisense oligonucleotides PMID:18351130
These results indicate that tNOX is suppressed during apoptosis and demonstrate that tNOX down-regulation sensitizes cells to stress-induced growth reduction, suggesting that tNOX is required for transformed cell growth. PMID:18789934

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Subcellular Location

Cell membrane. Secreted, extracellular space. Note=Extracellular and plasma membrane-associated.

Protein Families

ENOX family

Tissue Specificity

Found in the sera of cancer patients with a wide variety of cancers including breast, prostate, lung and ovarian cancers, leukemias, and lymphomas. Not found in the serum of healthy volunteers or patients with disorders other than cancer. Probably shed in

Database Links

HGNC: 2259

UNIGENE: Hs.171458

KEGG: hsa:10495

STRING: 9606.ENSP00000337146

OMIM: 300282

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