EGLN2 Antibody

1. 4-bp Insertion/deletion Polymorphism within the Promoter of EGLN2 is associated with breast cancer. PMID:29693343
2. Our study provided initial evidence that the insertion/deletion polymorphism rs10680577 may play a functional role in the development of CRC in the Chinese population PMID:28218358
3. In advanced-stage Hodgkin's Lymphoma patients strong cytoplasmic PHD1 expression in Reed-Sternberg cells was associated with poor relapse-free survival among patients treated with involved-field radiotherapy and advanced-stage patients treated with doxorubicin, bleomycin, vinblastine and darcabazine and involved-field radiotherapy. PMID:29277791
4. This study provides new information relating to the possible mechanism of therapeutic action of hydroxylase inhibitors that has been reported in pre-clinical models of intestinal and hepatic disease. PMID:27130823
5. PHD1 is phosphorylated by CDK2, CDK4 and CDK6 at Serine 130. PMID:26644182
6. siRNA-mediated knockdown of PHD1 inhibited glucose-stimulated insulin secretion in pancreatic Beta cells. PMID:26997627
7. EglN2 associates with the NRF1-PGC1alpha complex and controls mitochondrial function in breast cancer PMID:26492917
8. rs3733829 in the EGLN2 gene is significantly associated with the risk of COPD in Chinese populations of Hainan province. PMID:25609945
9. study conducted to investigate the association between gastric cancer (GC) susceptibility with a 4-bp insertion/deletion polymorphism (rs10680577) in the proximal promoter of EGLN2; findings showed that the heterozygote and the homozygote 4-bp del/del confer a significantly increased risk of GC PMID:24517638
10. Data indicate that the prolyl hydrolase 1 (PHD1) rs10680577 polymorphism is associated with the risk of non-small cell lung cancer in a Chinese population. PMID:24894671
11. PHD-1 played an important role in hypoxic response pathway of trophoblast through modulating the level of HIF-2alpha. PMID:24644426
12. PHD1 could induce cell cycle arrest in lung cancer cells, resulting in the suppression of cell proliferation. PMID:24935227
13. Results show that variants in two adjacent genes, EGLN2 and CYP2A6, influence smoking behavior related to disease risk. PMID:24045616
14. Onconeuronal antigen Cdr2 correlates with HIF prolyl-4-hydroxylase PHD1 and worse prognosis in renal cell carcinoma. PMID:23531419
15. Findings provided strong evidence for the hypothesis that rs10680577 contributes to hepatocarcinogenesis, possibly by affecting RERT-lncRNA structure and subsequently EGLN2 expression. PMID:23026137
16. miR-205 serves a protective role against both oxidative and endoplasmic reticulum stresses via the suppression of EGLN2 and subsequent decrease in intracellular reactive oxygen species. PMID:22859986
17. Principal component analysis of the covariance matrix of free AIRE-PHD1 highlights the presence of a "flapping" movement, which is blocked in an open conformation upon binding to H3K4me0. PMID:23077531
18. PHD1 expression correlated with high proliferation, and these tumors were mainly estrogen receptor-negative. PMID:21877141
19. Coexistence of PHD1 stabilized ATF4, as opposed to the destabilization of ATF4 by PHD3. PMID:21951999
20. human prolyl hydroxylase might play an important role in determining the physiology and structure of the corpora lutea during the menstrual cycle and early pregnancy PMID:20840881
21. role for PHD1 as a positive regulator of intestinal epithelial cell apoptosis in the inflamed colon PMID:20600011
22. Prolyl hydroxylase-dependent (but hypoxia inducible factor HIF-1alpha and -2alpha-independent) activation of hypoxia-induced monocyte-endothelial adhesion assigns a new function to monocytic ICAM-1 under acute hypoxic conditions. PMID:20574001
23. identified a human homolog of Caenorhabditis elegans Egl9 as a HIF prolyl hydroxylase PMID:12351678
24. effect of WT or mutated VHL on PHD 1, 2, and 3 PMID:15156561
25. defines the existence of two species of PHD1 and provide evidence that they are generated by alternative translational initiation PMID:16509823
26. Understanding the mechanisms by which nickel can inhibit HIF-PHD's and stabilize HIF-1alpha may be important in the treatment of cancer and ischemic diseases. PMID:16649251
27. Multiple mitochondrial products, including tricarboxylic acid intermediates and reactive oxygen species, can coordinate PHD activity, HIF stabilization, and cellular responses to O(2) depletion. PMID:17101781
28. hypoxia releases repression of NFkappaB activity through decreased prolyl hydroxylase-dependent hydroxylation of IKKbeta PMID:17114296
29. Results describe the expression, purification and characterization of the human prolyl hydroxylase PHD1 in Escherichia coli. PMID:18710826
30. The identification of EGLN2 as a significantly deregulated gene that maps within the paired chromosome region directly implicates defects in the oxygen-sensing network to the biology of renal oncocytoma. PMID:18773095
31. Overexpression of the oxygen sensor PHD-1 is associated with tumor aggressiveness in pancreatic endocrine tumors. PMID:18927305
32. Authors identify an interaction between melanoma antigen-11 (MAGE-11) cancer-testis antigen and the major HIF-alpha hydroxylating enzyme PHD2. PMID:19147576
33. Prolyl hydroxylase inhibitor reduced mitochondrial cytochrome c release, nuclear translocation of apoptosis inducing factor (AIF), and promoted Akt phosphorylation PMID:19229863

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HGNC: 14660

UNIGENE: Hs.515417

KEGG: hsa:112398

STRING: 9606.ENSP00000307080

OMIM: 606424