Cd46 Antibody

Code: CSB-PA004939LA01MO

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US$83

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Species Reactivity: Mouse

Raised in: Rabbit

Application: ELISA, WB, IHC

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Target Background

Product Details

Uniprot NO.

O88174

Target Names

Cd46

Alternative Names

Cd46 antibody; McpMembrane cofactor protein antibody; CD antigen CD46 antibody

Raised in

Rabbit

Species Reactivity

Mouse

Immunogen

Recombinant Mouse Membrane cofactor protein (45-329AA)

Immunogen Species

Mus musculus (Mouse)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Western Blot
Positive WB detected in: Mouse skeletal muscle tissue
All lanes: Cd46 antibody at 4µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 41, 34 kDa
Observed band size: 41 kDa
Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA004939LA01MO at dilution of 1:100

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Target Background

Function(From Uniprot)

May be involved in the fusion of the spermatozoa with the oocyte during fertilization.

Gene References into Functions

Changes in CD46 expression may lead to changes in VEGF and play a pathologic role in the development of age-related macular degeneration. PMID:26161984
Our findings provide evidence for expression of CD46 in the mouse eye and a role for CD46 in protection against laser-induced choroidal neovascularization PMID:25019227
This fusion is mediated by the interaction between viral glycoproteins expressed on the membrane of the infected cells and CD46 on the glial targets, and is also observed using cells expressing recombinant MV glycoproteins. PMID:15920733
CD46 isoforms function as receptors for human herpesvirus 6 and measles virus PMID:12171934
Disruption of mouse CD46 causes an accelerated spontaneous acrosome reaction in sperm and increased male fertility PMID:12640142
CD46 has a role as a receptor for fusion and entry of human herpesvirus 6 into target cells PMID:12724329

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Subcellular Location

[Isoform 1]: Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane; Single-pass type I membrane protein. Note=Inner acrosomal membrane of spermatozoa.; [Isoform 2]: Secreted.

Tissue Specificity

Present only in testis (at protein level).

Database Links

UNIGENE: Mm.12884

KEGG: mmu:17221

STRING: 10090.ENSMUSP00000123931

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