CYSLTR1 Antibody

1. The expression of CysLTR1 and CysLTR2 is higher in the lymphocytes of hyperplasic tonsils in nonallergic children PMID:27221082
2. SE sensitization may be a risk factor for TH2 inflammation in nonatopic asthma and late-onset asthma and for pulmonary function decline in nonatopic asthma. In women with asthma, a CysLTR1 promoter polymorphism may be associated with SEB sensitization. PMID:28034578
3. In addition, TGF-beta1-induced expression of MMP-1 and MMP-3, generation of fibronectin and type I collagen production, focal adhesion kinase (FAK) and paxillin phosphorylation in HTFs were also ameliorated by montelukast in a dose dependent manner. These results suggested that montelukast might provide therapeutic possibilities for inhibition of scar formation after such surgery. PMID:28088523
4. CysLTRs -1 and -2 seem to be involved in lymphocyte maturation that occurs in tonsils, without influence of allergies. PMID:27115897
5. Data show that cysteinyl leukotriene receptor antagonists (LTRAs) users had a significantly lower cancer incidence rate than LTRA non-users did. PMID:27052782
6. in allergen-sensitized individuals, exposure to allergen can enhance T cell expression of CysLT1. This, in turn, would induce enhanced CD4+ T cell responsiveness to cysLTs, T cell activation, and Th2 polarization. PMID:25918735
7. CysLTR-1 and CysLTR-2 are highly expressed in the adenoid tissues from children with AH, suggesting that leukotrienes are involved in the pathogenesis of AH. PMID:25760841
8. The 5-LOX/LTC4 /CysLT1 signaling pathway regulates EGF-induced cell migration by increasing Tiam1 expression. PMID:24350867
9. Cysteinyl leukotrienes signaling downstream of CysLT1R in mast cells is differentially regulated by two distinct PKCalpha and PKC epsilon. PMID:23977066
10. CysLT(1) receptors in endothelial cells translocate to the nucleus in a ligand-independent manner after ischemic insult in vitro, and it is involved in the ischemic injury. PMID:23085741
11. A significant relationship was found between the expression of CysLT1 receptor and GR-beta in nasal polyps (R = .525, P = .04), whereas there was no significant relationship between the expression of CysLT1 receptor and GR-alpha in nasal polyps. PMID:23124618
12. Genetic variant may play a role in NSAID induced acute urticaria. PMID:23181793
13. A role of nuclear CysLT(1) receptor signaling in vascular smooth muscle cells inducing gene expression patterns associated with atherosclerosis. PMID:22527886
14. Bronchial mucosal CysLT1 receptor-positive inflammatory cells are present in the bronchial mucosa in COPD in greatest number in those experiencing a severe exacerbation. PMID:22871757
15. increased expression in tonsillar tissues of Chinese children with sleep-disordered breathing PMID:22634478
16. Data suggest that CysLT1 induces chemokine-like effects, supports accumulation and survival of chronic lymphocytic leukemia (CLL) cells in the bone marrow and thus represents a potential treatment target. PMID:21936770
17. cysteinyl-leukotriene receptors are differently expressed in fibroblast from peripheral versus central airways in asthmatics and healthy controls. PMID:21596548
18. upon ligand activation, CysLT(1)R is tyrosine-phosphorylated and released from heterodimers with CysLT(2)R and, subsequently, internalizes from the plasma membrane to the nuclear membrane in a clathrin-, arrestin-3-, and Rab-5-dependent manner PMID:21203429
19. CysLT1-R expression following allergen provocation in asthma and allergic rhinitis. PMID:20462748
20. Data show functional expression of CysLT1 and 2 receptors on human platelets and demonstrate that CysLTs induced the release of significant amounts of RANTES, which suggests a novel role for human platelets in CysLT-mediated allergic inflammation. PMID:20433311
21. Genetic variants of CYSLTR1 promoter might be associated with gender specific expression of CysLT1 alternative transcripts in patients with asthma. PMID:20003473
22. interaction of CysLTs and CysLT(1) on eosinophils has the potential to play a prominent role in the pathophysiology of asthma. PMID:12373000
23. CysLT1R expression, up-regulated by IL-13 and leukotriene C4, may contribute to eotaxin production by lung fibroblasts. PMID:12682264
24. CysLT1 receptor upregulation by TGF-beta and IL-13 is associated with bronchial smooth muscle cell proliferation in response to LTD4. PMID:12743568
25. Arachidonic acid inhibits cysteinyl-leukotriene receptor activation in human pulmonary vessels PMID:12751740
26. upregulated in colon cancer; affecting survival PMID:12751768
27. the importance of increased CysLT signaling in airway smooth muscle function PMID:15064240
28. CysLT1R as the first G protein-coupled receptor identified to date in which protein kinase C is the principal regulator of both rapid agonist-dependent internalization. PMID:15590629
29. CysLT 1 expression predominates on inflammatory leukocytes in aspirin-sensitive rhinosinusitis. Effects of cysteinyl leukotrienes on glands and epithelium may be mediated predominantly through cysLT 2. Potentially important therapeutic implications. PMID:15696087
30. There is increased nuclear localization of the CysLT(1) receptor in colorectal adenocarcinomas. PMID:15705869
31. upregulation of cysteinyl leukotriene-1 receptor is associated with asthma PMID:16123393
32. Leukotriene D4, via the CysLT1 receptor, can transcriptionally activate IL-8 production, with involvement of the transcription factors p50, p65, Fos, and Jun. PMID:16809637
33. The 927T>C CYSLTR1 SNP was analyzed by direct sequencing after PCR amplification in childres with asthma and atopic dermatitis. PMID:16846449
34. In the group of male patients, the C allele of 927T> C CYSLTRI was more common among patients with asthma than controls PMID:17153879
35. Desensitization of the CysLT1R is the principal mechanism by which PKC regulates the functional consequences of its desensitization in tracheea smooth muscle. PMID:17392478
36. analysis of polymorphism and differential regulation of CYSLTR1 transcription in human airway smooth muscle and monocytes PMID:17406065
37. Overexpression of cysteinyl LT1 receptor is associated with prostate cancer PMID:17549353
38. discovered a CysLT1 G300S variant that is carried with a significantly higher frequency in atopics and asthmatics from the Tristan da Cunha population PMID:17558309
39. CysLTR1 polymorphism may contribute to development of the aspirin-intolerant asthma phenotype and can be used as a genetic marker for differentiating two major aspirin hypersensitivity phenotypes. PMID:17641958
40. CysLT2R signaling leads to terminal differentiation of colon carcinoma cells and growth inhibition, and its expression is relatively high in less malignant forms of colon cancer. PMID:17909024
41. CysLTR1 promoter polymorphism is a useful genetic marker for predicting leukotriene receptor antagonist requirement in aspirin intolerant asthma patienets PMID:17924829
42. CysLT1R and CysLT2R expression in monocytes can be regulated by CysLT itself and T(H)2 cytokines at the transcriptional level. PMID:17941281
43. Our data show that CysLTs acting through CysLTR(1) can significantly influence the activation and migration of human monocytes. PMID:18028998
44. STAT-1 is involved in the signal transduction mechanism associated with cysteinyl leukotriene receptor 1 activation, supporting the hypothesis that it may represent a key transduction pathway leading to enhanced eosinophil adhesiveness. PMID:18305014
45. CysLT1 is involved in remodeling processes through modulation of furin transcription. PMID:18323532
46. Report the long-term effect of Helicobacter pylori eradication on COX-1/2, 5-LOX and leukotriene receptors in patients with a risk gastritis phenotype--a link to gastric carcinogenesis. PMID:18571838
47. Results demonstrate that cysteinyl leucotrienes cause contraction in the human and guinea-pig oesophagus, which is mediated by the cysteinyl leucotriene receptor type 1. PMID:18651869
48. SNP rs320995 in the cysteinyl leukotriene receptor 1 gene was associated with risk of asthma PMID:18829683
49. The combined study of polymorphisms in genes of the leukotriene pathway could explain the differences observed in the studies reported on polymorphism -444A < C LTC4S individually analysed. PMID:19080797
50. The most potent CysLT(1) ligand, LTD(4), rapidly and significantly up-regulated alpha(4)beta(1) and alpha(5)beta(1) integrin-dependent adhesion of both primitive and committed hematopoietic progenitor cells PMID:19454674

Show More

Hide All

HGNC: 17451

UNIGENE: Hs.733809

KEGG: hsa:10800

STRING: 9606.ENSP00000362401

OMIM: 300201