CSMD3 Antibody

Code: CSB-PA800102LA01HU

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US$83

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Species Reactivity: Human

Raised in: Rabbit

Application: ELISA, IHC, IF

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Target Background

Product Details

Uniprot NO.

Q7Z407

Target Names

CSMD3

Alternative Names

CSMD3 antibody; KIAA1894CUB and sushi domain-containing protein 3 antibody; CUB and sushi multiple domains protein 3 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human CUB and sushi domain-containing protein 3 protein (233-380AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:200-1:500
IF	1:50-1:200

Protocols

ELISA Protocol Immunohistochemistry (IHC) Protocol Immunofluorescence (IF) Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

IHC image of CSB-PA800102LA01HU diluted at 1:400 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Immunofluorescence staining of HepG2 cells with CSB-PA800102LA01HU at 1: 133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized tissue using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C.The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) .

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Target Background

Function(From Uniprot)

Involved in dendrite development.

Gene References into Functions

Nonsynonymous variants of CSMD3 is associated with familial colorectal cancer. PMID:21351276
CSMD3 encodes a protein with CUB and sushi multiple domains and is a candidate gene for benign adult familial myoclonic epilepsy on human chromosome 8q23.3-q24.1 PMID:12943675
Breakpoints on chromosomes 8 in both patients do not interrupt any known gene but both map in a region containing the CSMD3 gene, which thereby can be considered as a candidate for autistic spectrum disorders PMID:18270536
Single-nucleotide polymorphisms in CSMD3 is associated with prostate cancer risk in hispanic men. PMID:19528667
CSMD3 is deleted in a subject with combined tricho-rhino-phalangeal syndrome II with mental retardation and growth hormone deficiency. PMID:15523607
CSMD3 protein domain structure and the sequence of the cytoplasmic tail are highly conserved between mammals and fish. PMID:12906867

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Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Families

CSMD family

Tissue Specificity

Weakly expressed in most tissues, except in brain. Expressed at intermediate level in brain, including cerebellum, substantia nigra, thalamus, spinal cord, hippocampus and fetal brain. Also expressed in testis.

Database Links

HGNC: 19291

UNIGENE: Hs.91381

KEGG: hsa:114788

STRING: 9606.ENSP00000297405

OMIM: 608399

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