CNGA2 Antibody

Code: CSB-PA001733

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Size:

50μg100μg

US$119

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Species Reactivity: Human,Mouse,Rat

Raised in: Rabbit

Application: WB, IF, ELISA

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Product Details
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Target Background

Product Details

Uniprot NO.

Q16280

Target Names

CNGA2

Alternative Names

CNCA antibody; CNCA1 antibody; CNCG2 antibody; CNG 2 antibody; CNG channel alpha 2 antibody; CNG channel alpha-2 antibody; CNG-2 antibody; CNG2 antibody; CNGA 2 antibody; Cnga2 antibody; CNGA2_HUMAN antibody; Cyclic nucleotide gated cation channel 2 antibody; Cyclic nucleotide gated channel alpha 2 antibody; Cyclic nucleotide gated olfactory channel antibody; Cyclic nucleotide-gated cation channel 2 antibody; Cyclic nucleotide-gated channel alpha-2 antibody; Cyclic nucleotide-gated olfactory channel antibody; FLJ46312 antibody; OCNC1 antibody; OCNCa antibody; OCNCALPHA antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthesized peptide derived from the Internal region of Human CNG-2.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Tested Applications

WB, IF, ELISA

Protocols

Western Blotting(WB) Protocol Immunofluorescence (IF) Protocol ELISA Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Western Blot analysis of K562 cells using CNG-2 Polyclonal Antibody
Western Blot analysis of various cells using CNG-2 Polyclonal Antibody

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function(From Uniprot)

Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons.

Gene References into Functions

The studies findings provides strong support for role of CNGA2 gene with pathogenicity of isolated congenital anosmia in humans. Together, these results indicate that mutations in key olfactory signaling pathway genes are responsible for human disease. PMID:28572688
Identification of a novel X-linked stop mutation in CNGA2 (c.634C>T, p.R212*) in two brothers with isolated congenital anosmia. PMID:25156905
The results showed that it is predominantly the charge of the E342 residue in the P-loop, rather than the pore helix dipoles, which controls the cation-anion selectivity of the CNGA2 channel. PMID:16533895

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Subcellular Location

Membrane; Multi-pass membrane protein.

Protein Families

Cyclic nucleotide-gated cation channel (TC 1.A.1.5) family, CNGA2 subfamily

Database Links

HGNC: 2149

UNIGENE: Hs.447360

KEGG: hsa:1260

STRING: 9606.ENSP00000328478

OMIM: 300338

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