CNGA2 Antibody

Code: CSB-PA139476

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Size:

100μl

US$297

Quantity:

Species Reactivity: Human,Mouse

Raised in: Rabbit

Application: ELISA,IF

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Target Background

Product Details

Uniprot NO.

Q16280

Target Names

CNGA2

Alternative Names

CNCA antibody; CNCA1 antibody; CNCG2 antibody; CNG 2 antibody; CNG channel alpha 2 antibody; CNG channel alpha-2 antibody; CNG-2 antibody; CNG2 antibody; CNGA 2 antibody; Cnga2 antibody; CNGA2_HUMAN antibody; Cyclic nucleotide gated cation channel 2 antibody; Cyclic nucleotide gated channel alpha 2 antibody; Cyclic nucleotide gated olfactory channel antibody; Cyclic nucleotide-gated cation channel 2 antibody; Cyclic nucleotide-gated channel alpha-2 antibody; Cyclic nucleotide-gated olfactory channel antibody; FLJ46312 antibody; OCNC1 antibody; OCNCa antibody; OCNCALPHA antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthesized peptide derived from internal of Human CNGA2.

Immunogen Species

Homo sapiens (Human)

Clonality

Polyclonal

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Tested Applications

ELISA,IF

Protocols

ELISA Protocol Immunofluorescence (IF) Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Immunofluorescence analysis of A549 cells, using CNGA2 antibody.

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Target Background

Function(From Uniprot)

Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons.

Gene References into Functions

The studies findings provides strong support for role of CNGA2 gene with pathogenicity of isolated congenital anosmia in humans. Together, these results indicate that mutations in key olfactory signaling pathway genes are responsible for human disease. PMID:28572688
Identification of a novel X-linked stop mutation in CNGA2 (c.634C>T, p.R212*) in two brothers with isolated congenital anosmia. PMID:25156905
The results showed that it is predominantly the charge of the E342 residue in the P-loop, rather than the pore helix dipoles, which controls the cation-anion selectivity of the CNGA2 channel. PMID:16533895

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Subcellular Location

Membrane; Multi-pass membrane protein.

Protein Families

Cyclic nucleotide-gated cation channel (TC 1.A.1.5) family, CNGA2 subfamily

Database Links

HGNC: 2149

UNIGENE: Hs.447360

KEGG: hsa:1260

STRING: 9606.ENSP00000328478

OMIM: 300338

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