CD52 Antibody

Code: CSB-PA338154

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Size:

50μg100μg

US$119

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Species Reactivity: Human

Raised in: Rabbit

Application: IHC,ELISA

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Target Background

Product Details

Uniprot NO.

P31358

Target Names

CD52

Alternative Names

Cambridge pathology 1 antigen antibody; CAMPATH 1 antibody; CAMPATH 1 antigen antibody; CAMPATH-1 antigen antibody; CD 52 antibody; CD52 antibody; CD52 antigen antibody; CD52 molecule antibody; CD52_HUMAN antibody; CDw52 antibody; CDW52 antigen antibody; Epididymal secretory protein E5 antibody; Epididymis secretory sperm binding protein Li 171mP antibody; HE 5 antibody; He5 antibody; Human epididymis-specific protein 5 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide from Human protein at AA range: 20-50

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Purification Method

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Tested Applications

IHC,ELISA

Protocols

Immunohistochemistry (IHC) Protocol ELISA Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Immunohistochemical analysis of paraffin-embedded Human-tonsil, antibody was diluted at 1:100
Immunohistochemical analysis of paraffin-embedded Human-spleen, antibody was diluted at 1:100

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Target Background

Function(From Uniprot)

May play a role in carrying and orienting carbohydrate, as well as having a more specific role.

Gene References into Functions

soluble CD52 exerts a concerted immunosuppressive effect by first sequestering HMGB1 to nullify its proinflammatory Box B, followed by binding to the inhibitory Siglec-10 receptor, triggering recruitment of SHP1 to the intracellular immunoreceptor tyrosine-based inhibitory motif of Siglec-10 and its interaction with the TCR. PMID:29997173
CD52 is a novel prognostic NSC marker and a potential NSC target in a subset of patients with MDS and AML, which may have clinical implications and may explain clinical effects produced by alemtuzumab in these patients. PMID:24799522
carbohydrate moiety of sperm protein interferes with the complement system via binding to C1q PMID:22386526
CT60 single-nucleotide polymorphism of CTLA4 is a surrogate marker for donor lymphocyte infusion outcome after allogeneic cell transplantation for acute leukemia PMID:21552305
Clonal large granular lymphocytes exhibited decreased CD52 expression post-therapy in patients refractory to treatment. PMID:19794084
Our bioinformatics findings suggest that CD52 polymorphism may affect the efficiency of GPI anchor formation and thus may indirectly alter the response to anti-CD52 agents like alemtuzumabin renal transplantation. PMID:20349607
Review article on CD52 structure and function. PMID:11860230
HE5(CD52) mRNA and protein, expressed in epithelial cells of the distal epididymis, were not affected by the obstruction of the vas deferens. PMID:14662784
The relationship between this differential insertion and differences in glycosylation of rat and human CD52 is discussed. PMID:16266689
CD52 is widely expressed on human mast cells (MCs) and Waldenstrom's Macroglobulinemia bone marrow lymphoplasmacytic cells and provide the preclinical rationale for the use of alemtuzumab in the treatment of WM and possibly other MC-related disorders. PMID:16796779
In this study, we identified the antigen of 4C8 mAb as CD52. CD52 is a costimulatory molecule for induction of CD4-positive T cells. PMID:16797237
In contrast with CLL, the variable expression of CD52 among other hematologic malignancies suggests that target validation on a case-by-case basis will likely be necessary to guide the rational analysis of CAMPATH therapy. PMID:17145843
Our data demonstrate differences in the intensity of the CD52 antigen expression between B-lymphocytes and tumor lymphocytes of B-CLL patients, and between B-CLL and SLL tumor cells. CD52 antigen is expressed at low level on CD34(+) cells. PMID:17428002
The semenogelin-CD52 soluble form is a direct consequence of the liquefaction process in human semen. PMID:17624925
We first showed the expression of CD52 in human cumulus cells. CD52 has some functional roles around fertilization in females as well as in males. PMID:18647288
A review on CD52 expression and function PMID:11257744