CCRL2 Antibody

CSB-PA004852LA01HU

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US$83

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Species Reactivity: Human

Raised in: Rabbit

Application: ELISA, WB, IHC

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Product Details
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Target Background

Product Details

Uniprot NO.

O00421

Target Names

CCRL2

Alternative Names

CCRL2; CCR11; CCR6; CKRX; CRAM; HCR; C-C chemokine receptor-like 2; Chemokine receptor CCR11; Chemokine receptor X; Putative MCP-1 chemokine receptor

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human C-C chemokine receptor-like 2 protein (1-43AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Protocols

ELISA Protocol Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol

Datasheet & COA

Antibody FAQs

Images

Western Blot
Positive WB detected in: HL60 whole cell lysate
All lanes: CCRL2 antibody at 2.5µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 40, 41 kDa
Observed band size: 40 kDa
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA004852LA01HU at dilution of 1:100

Description

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Target Background

Function

Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses.

Gene References into Functions

CCRL2 mRNA was not significantly changed in murine and human non-alcoholic steatohepatitis liver. CCRL2 mRNA levels were positively correlated with inflammation, fibrosis and NASH scores in the patients. PMID:28600126
CCRL2 inhibited the growth of breast cancer cells in vitro and in vivo. PMID:26487662
in breast cancer, CRAM-A becomes specifically upregulated under inflammatory stimuli and may serve as a potential marker of immune response. PMID:26563945
these results suggest for the first time that elevated CCRL2 in glioma promotes cell migration and invasion. PMID:23142225
Considering the newly defined role of CCRL2 in lung dendritic cell trafficking, this atypical chemokine receptor may affect pneumocystis pneumonia through immune regulation and inducing inflammation. PMID:22046140
demonstration that the homeostatic chemokine CCL19 is a specific ligand for CRAM PMID:20002784
CCRL2 expression is up-regulated on synovial neutrophils of rheumatoid arthritis patients PMID:15188357
Results identify chemerin as a natural nonsignaling protein ligand for both human and mouse CCRL2. PMID:18794339

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Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Families

G-protein coupled receptor 1 family

Tissue Specificity

Expressed abundantly in immunal tissues such as spleen, fetal liver, lymph node and bone marrow. Strong expression also in lung and heart. Expressed in almost all hematopoietic cells including monocytes, macrophages, PMNs, T-cells (both CD4+ and CD8+), mo

Database Links

HGNC: 1612

UNIGENE: Hs.535713

KEGG: hsa:9034

STRING: 9606.ENSP00000349967

OMIM: 608379

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