CCL16 Antibody

Code: CSB-PA08967A0Rb

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20μg50μg100μg

US$83

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Species Reactivity: Human

Raised in: Rabbit

Application: ELISA

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Target Background

Product Details

Uniprot NO.

O15467

Target Names

CCL16

Alternative Names

C-C motif chemokine 16 antibody; CCL16 antibody; CCL16_HUMAN antibody; Chemokine (C-C motif) ligand 16 antibody; Chemokine CC-4 antibody; Chemokine LEC antibody; CKb12 antibody; HCC-4 antibody; HCC4 antibody; IL-10-inducible chemokine antibody; IL10 inducible chemokine antibody; IL10 inducible chemokine antibody; ILINCK antibody; LCC-1 antibody; LCC1 antibody; Liver CC chemokine 1 precursor antibody; Liver expressed chemokine antibody; Liver-expressed chemokine antibody; LMC antibody; Lymphocyte and monocyte chemoattractant antibody; Monotactin 1 antibody; Monotactin-1 antibody; MTN-1 antibody; Mtn1 antibody; NCC-4 antibody; NCC4 antibody; New CC chemokine 4 antibody; SCYA16 antibody; SCYL4 antibody; Small inducible cytokine A16 precursor antibody; Small inducible cytokine A16 precursor antibody; Small inducible cytokine subfamily A (Cys Cys) member 16 antibody; Small-inducible cytokine A16 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human C-C motif chemokine 16 protein (24-120AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Tested Applications

ELISA

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Target Background

Function(From Uniprot)

Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES.

Gene References into Functions

Overexpression of miR-1247 may alleviate LPS-induced A549 cell injury through targeting CCL16. PMID:29768218
Single nucleotide polymorphism (SNPs) located in and around the C-C motif chemokine ligand 16 (CCL16) gene are associated with CCL16 protein levels in blood plasma, and rs80329614 is the SNP most strongly associated with CCL16 protein levels in plasma. PMID:27357396
High umbilical artery CCL16 is prominently detected in preterm preeclamptic pregnancies with severe growth restriction. PMID:22857868
Data show that CCL-16 gene expression was upregulated by 7.46-fold in IBS patients when compared with controls and suggest a subclinical inflammatory component underlying IBS. PMID:21951809
Low umbilical cord blood chemokine CCL16 associates with spontaneous preterm birth PMID:21288736
Recombinant CCL16 significantly enhances the effector and the antigen-presenting function of macrophages and augments T cell lytic activity. PMID:14525962
An adenoviral vector encoding human CCL16 injected into mice with pre-established mammary carcinoma induces strong antitumor response; when given before surgical excision of primary lesions, the treatment prevents metastatic spread and cures 63% of mice. PMID:15034014
CCL16 induced efficient migratory responses in human and mouse eosinophils. CCL16 is a novel functional ligand for H4 and may have a role in trafficking of eosinophils. PMID:15265943
CC chemokine-4 (HCC-4)/CCL16 transduces signals differently from other CCR1-dependent chemokines and may play different roles in the immune response. PMID:16226254
Elevated concentrations in bronchoalveolar lavage fluid from patients with eosinophilic pneumonia PMID:19494526

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Subcellular Location

Secreted.

Protein Families

Intercrine beta (chemokine CC) family

Tissue Specificity

Mainly expressed in liver, also found in spleen and thymus. Highly expressed in LPS- and IFN-gamma-activated monocytes, weakly in some lymphocytes, including natural killer cells, gamma-delta T-cells, and some T-cell clones.

Database Links

HGNC: 10614

UNIGENE: Hs.10458

KEGG: hsa:6360

STRING: 9606.ENSP00000293275

OMIM: 601394

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