VSIR Antibody, FITC conjugated

Code: CSB-PA884484LC01HU

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50μg100μg

US$166

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Species Reactivity: Human

Raised in: Rabbit

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Target Background

Product Details

Uniprot NO.

Q9H7M9

Target Names

VSIR

Alternative Names

B7 H5 antibody; B7H5 antibody; C10orf54 antibody; chromosome 10 open reading frame 54 antibody; DD1alpha antibody; GI24 antibody; GI24_HUMAN antibody; PD-1H antibody; PDCD1 homolog antibody; Platelet receptor Gi24 antibody; PP2135 antibody; sisp 1 antibody; SISP1 antibody; stress induced secreted protein 1 antibody; UNQ730/PRO1412 antibody; V domain Ig suppressor of T cell activation antibody; V set domain containing immunoregulatory receptor antibody; V set immunoregulatory receptor antibody; V type immunoglobulin domain containing suppressor of T cell activation antibody; VISTA antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human V-type immunoglobulin domain-containing suppressor of T-cell activation protein (37-194AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

FITC

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Target Background

Function(From Uniprot)

Immunoregulatory receptor which inhibits the T-cell response. May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling. May stimulate MMP14-mediated MMP2 activation.

Gene References into Functions

Data indicate that VISTA is predominantly expressed and up-regulated in the high-density infiltrated immune cells but minimal in pancreatic cancerous cells. PMID:29771768
High VISTA expression is associated with colorectal carcinoma. PMID:30128738
VISTA expression supports immune-complex inflammation in collagen antibody-induced arthritis and VISTA is expressed in human synovium PMID:29216931
This study is the first to describe the expression of VISTA-expressing lymphocytes in melanoma samples and in the context of acquired resistance to immune checkpoint inhibitors PMID:28776578
Taken together, the results indicated that the VISTA high and CD8 low group, as an immunosuppressive subgroup, might be associated with a poor prognosis in primary OSCC. These findings indicated that VISTA might be a potential immunotherapeutic target in OSCC treatment. PMID:28236118
this review describes the functions of VISTA in the context of cancer immunotherapy PMID:28258694
overexpression of the newly described co-stimulatory molecule, PD1 homologue (PD-1H) in human monocyte/macrophages is sufficient to induce spontaneous secretion of multiple cytokines. PMID:25279955
p53-induced expression of DD1alpha prevents persistence of cell corpses and ensures efficient generation of precise immune responses in mice. PMID:26228159
Results suggest that GI24 contributes to tumor-invasive growth in the collagen matrix by augmenting cell surface MT1-MMP. PMID:20666777

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Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Tissue Specificity

Expressed in spleen. Detected on a number of myeloid cells including CD11b monocytes, CD66b+ neutrophils, at low levels on CD4+ and CD8+ T-cells, and in a subset of NK cells. Not detected on B cells (at protein level). Expressed at high levels in placenta

Database Links

HGNC: 30085

UNIGENE: Hs.47382

KEGG: hsa:64115

STRING: 9606.ENSP00000378409

OMIM: 615608

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