BOLL Antibody

CSB-PA854082ESR2HU

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20μl50μl100μl

US$83

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Species Reactivity: Human

Raised in: Rabbit

Application: ELISA, IHC

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Target Background

Product Details

Uniprot NO.

Q8N9W6

Target Names

BOLL

Alternative Names

Bol (Drosophila boule homolog) like antibody; Bol antibody; Bol boule like antibody; Bol, boule like (Drosophila) antibody; bol, boule-like (Drosophila) antibody; Boll antibody; BOLL_HUMAN antibody; BOULE antibody; Boule like antibody; BOULE, Drosophila, homolog of antibody; Protein boule like antibody; Protein boule-like antibody; Putative uncharacterized protein BOLL antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Protein boule-like protein (1-283AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Protocols

ELISA Protocol Immunohistochemistry (IHC) Protocol

Datasheet & COA

Antibody FAQs

Images

Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA854082ESR2HU at dilution of 1:100

Description

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Target Background

Function

Probable RNA-binding protein, which may be required during spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation.

Gene References into Functions

hypermethylation of DAZL and BOULE promoters in human sperm is associated with human infertility PMID:27358391
Our study demonstrated an oncogenic role of BOLL in CRC despite tumor-specific promoter hypermethylation. PMID:25605553
demonstrate that Boll is also transiently expressed during oogenesis in the fetal mouse ovary, but is simultaneously co-expressed within the same germ cells as Dazl PMID:24086306
Assessing the expression of both CDY1 and BOULE by qualitative RT-PCR is a sensitive and feasible test for predicting the presence of sperm cells in testicular tissue biopsies. PMID:21474125
expression of spermatogenic phenotypes of partial AZFc deletions is independent of the variations in DAZL and BOULE in the Han population PMID:19342699
BOULE may encode a key conserved switch that regulates progression of germ cells through meiosis in men. PMID:12499397
Role in spermatogenesis. Decreased DAZ proteins in spermatogenic failure may be due to germ cell loss. Transcription of BOULE, DAZL, and DAZ not altered in degrees of spermatogenic failure. No increase of DAZL or BOULE found in DAZ deletion. PMID:15066460
Major group of infertile men with meiotic arrest lack BOULE protein and its putative target, CDC25A expression. Spermatogenic failure may arise from factor(s) upstream of BOULE possibly involved in regulating transcription and/or translation of BOULE. PMID:15070965
BOULE coding sequence mutations are not an important factor in the aetiology of azoospermia. PMID:15379971
mutations in BOULE can be eliminated as a major cause of impaired spermatogenesis. PMID:15705409
Among the three BOULE isoforms, B2 might have the major role for meiotic completion. PMID:17114206
CDC25A is subject to translational control by BOLL, which is an evolutionarily conserved mechanism. PMID:19417033
human DAZL (deleted in azoospermia-like) functions in primordial germ-cell formation, whereas closely related genes DAZ and BOULE (also called BOLL) promote later stages of meiosis and development of haploid gametes PMID:19865085

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Subcellular Location

Cytoplasm.

Protein Families

RRM DAZ family

Tissue Specificity

Testis specific. Not expressed in early embryos, primordial germ cells and spermatogonial cells. First expressed in the cytoplasm of spermatocytes and then persists through meiosis.

Database Links

HGNC: 14273

UNIGENE: Hs.169797

KEGG: hsa:66037

STRING: 9606.ENSP00000314792

OMIM: 606165

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