BAG2 Antibody

Code: CSB-PA002530ESR1HU

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20μl50μl100μl

US$83

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Species Reactivity: Human

Raised in: Rabbit

Application: ELISA, WB, IHC

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Product Details
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Target Background

Product Details

Uniprot NO.

O95816

Target Names

BAG2

Alternative Names

BAG 2 antibody; BAG family molecular chaperone regulator 2 antibody; BAG-2 antibody; BAG-family molecular chaperone regulator-2 antibody; Bag2 antibody; BAG2_HUMAN antibody; BCL 2 associated athanogene 2 antibody; Bcl-2-associated athanogene 2 antibody; BCL2 associated athanogene 2 antibody; BCL2-associated athanogene 2 antibody; dJ417I1.2 (BAG family molecular chaperone regulator 2) antibody; dJ417I1.2 antibody; KIAA0576 antibody; MGC149462 antibody; OTTHUMP00000016668 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human BAG family molecular chaperone regulator 2 protein (1-211AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Protocols

ELISA Protocol Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Western blot
All lanes: BAG family molecular chaperone regulator 2 antibody at 6μg/ml
Lane 1: Jurkat whole cell lysate
Lane 2: Hela whole cell lysate
Lane 3: HepG2 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 24, 21 kDa
Observed band size: 24 kDa
Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA002530ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA002530ESR1HU at dilution of 1:100

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release.

Gene References into Functions

the nucleotide exchange factor (NEF) Bag2 stimulates SV40 release from Hsc70, thereby enabling successful virus arrival at the cytosol, which leads to infection. Hsp105, another NEF of Hsc70, displays a function overlapping that of Bag2, underscoring the importance of this release reaction. PMID:29769335
A comprehensive review of the structure, functions, and protein interactions of BAG2 PMID:28536620
Data show that BAG2 Inhibits CHIP-Mediated HSP72 ubiquitination in aged cells. PMID:28042827
repression of BAG2 expression or BAG2 activity by cold-sensitive pathways, as modeled in undifferentiated and differentiated cells, respectively, may be a causal factor in the accumulation of cytotoxic hyperphosphorylated tau protein. PMID:26208804
NF-kappaB-mediated modulation of BAG2 expression regulates the shift between the neurotrophic and neurotoxic effects of Abeta1-42. PMID:25985852
Thus, BAG2 promotes mutant p53 accumulation and gain-of-function in tumor growth, metastasis and chemoresistance. PMID:26271008
This study showed that BAG2 (Bcl-2 associated athanogene family protein 2) and BAG5 (Bcl-2-associated athanogene family protein 5) stabilise pathogenic ataxin3-80Q by inhibiting its ubiquitination PMID:25006867
this data correlate BAG2 to PINK1 for the first time, strengthening the important role of BAG2 in Parkinson disease -related neurodegeneration. PMID:24383081
BAG2 binds to the carboxyl terminus of Hsp70-interacting protein (CHIP) and provides a cochaperone-dependent regulatory mechanism for preventing unregulated ubiquitylation of misfolded proteins by CHIP PMID:16169850
The activity of BAG-2 resembles that of the previously characterized Hsc70 cochaperone and CHIP inhibitor HspBP1. PMID:16207813