AMPH Antibody

Code: CSB-PA796280

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Size:

50μl100μl

US$166

Quantity:

Species Reactivity: Human,Mouse

Raised in: Rabbit

Application: ELISA,WB,IHC

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Product Details
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Target Background

Product Details

Uniprot NO.

P49418

Target Names

AMPH

Alternative Names

Amp antibody; AMPH 1 antibody; AMPH antibody; AMPH_HUMAN antibody; AMPH1 antibody; Amphiphysin (Stiff-Man syndrome with breast cancer 128kD autoantigen) antibody; Amphiphysin (Stiff-Man syndrome with breast cancer 128kDa autoantigen) antibody; Amphiphysin antibody; Amphiphysin I antibody; CG8604 antibody; Damp antibody; dAmph antibody; Dmel\CG8604 antibody; HGNC:471 antibody; MGC49429 antibody; Stiff man syndrome with breast cancer 128kD autoantigen antibody; Stiff man syndrome with breast cancer 128kDa autoantigen antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Fusion protein of Human AMPH

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Tested Applications

ELISA,WB,IHC

Protocols

ELISA Protocol Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA796280(AMPH Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA796280(AMPH Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
Gel: 10%SDS-PAGE, Lysate: 60 μg, Lane: Mouse lung tissue, Primary antibody: CSB-PA796280(AMPH Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute

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Target Background

Function(From Uniprot)

May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton.

Gene References into Functions

The data show that the dynamin-amphiphysin helices are rearranged to form clusters upon GTP hydrolysis and membrane constriction occurs at protein-uncoated regions flanking the clusters. PMID:29357276
We show that AMPH-1/BIN1 binds to nesprin and actin, as well as to the microtubule-binding protein CLIP170 in both species. We propose that BIN1 has a direct and evolutionarily conserved role in nuclear positioning, altered in myopathies. PMID:26506308
It is a nerve protein and its autoantibody causes paraneoplastic neurological syndromes. PMID:25087559
AMPH1 protein level is reduced in transgenic mouse brain proteins. in the brainstem of nontransgenic and terminally ill JNPL3 transgenic mice. PMID:22975846
We propose that antibody-mediated amphiphysin deficiency may account for anxiety behavior in stiff person syndrome PMID:22331304
structure-based approach to prediction of peptide-binding behavior of SH3 domain of amphiphysin-1: statistical modeling PMID:19669081
investigation of binding affinities of decapeptide ligands with amphiphysin SH3 domain using QSAR models PMID:20214647
Female patient with amphiphysin autoantibodies and siff leg syndrome due to small cell cancer of the lung. PMID:16671079
Amphiphysin I (Amph I) is a minibrain kinase/dual-specificity tyrosine phosphorylation-regulated kinase substrate. Amph I phosphorylation changes the recruitment of endophilin at the endocytic sites. PMID:16733250
This study demonstrates that the analysis of the molecular interaction energy components between peptides and the SH3 domain can successfully characterize the binding interface. PMID:18206907
Analyses of Gaussian distribution models showed that diversified properties contribute to the interactions between the SH3 domain and of amphiphysin and peptides. PMID:18814309